Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4256634..4257435 Replicon chromosome
Accession NZ_CP062895
Organism Escherichia coli strain Res13-Lact-ER02-39

Toxin (Protein)


Gene name yeeV Uniprot ID D8EBK0
Locus tag IMP38_RS20585 Protein ID WP_001094436.1
Coordinates 4257058..4257435 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MN76
Locus tag IMP38_RS20580 Protein ID WP_015953067.1
Coordinates 4256634..4257011 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP38_RS20545 4252546..4253226 + 681 WP_001282927.1 WYL domain-containing protein -
IMP38_RS20550 4253374..4254051 + 678 WP_001097312.1 hypothetical protein -
IMP38_RS20555 4254057..4254290 + 234 WP_001278287.1 DUF905 family protein -
IMP38_RS20560 4254380..4255198 + 819 WP_001175142.1 DUF945 domain-containing protein -
IMP38_RS20565 4255289..4255774 + 486 WP_000860054.1 antirestriction protein -
IMP38_RS20570 4255789..4256265 + 477 WP_001186756.1 RadC family protein -
IMP38_RS20575 4256334..4256555 + 222 WP_000692312.1 DUF987 domain-containing protein -
IMP38_RS20580 4256634..4257011 + 378 WP_015953067.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
IMP38_RS20585 4257058..4257435 + 378 WP_001094436.1 TA system toxin CbtA family protein Toxin
IMP38_RS20590 4257432..4257920 + 489 WP_000761714.1 hypothetical protein -
IMP38_RS20595 4257932..4258129 + 198 WP_000839254.1 DUF957 domain-containing protein -
IMP38_RS20600 4258214..4259059 + 846 WP_001280513.1 DUF4942 domain-containing protein -
IMP38_RS20605 4259130..4260665 + 1536 WP_000492897.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13958.84 Da        Isoelectric Point: 6.8603

>T177205 WP_001094436.1 NZ_CP062895:4257058-4257435 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ

Download         Length: 378 bp

>T177205 NZ_CP083274:4170881-4171279 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13766.60 Da        Isoelectric Point: 6.2021

>AT177205 WP_015953067.1 NZ_CP062895:4256634-4257011 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT177205 NZ_CP083274:4170585-4170878 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L1N0

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z3CIS0

References