Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/- |
Location | 42156..42532 | Replicon | plasmid unnamed973 |
Accession | NZ_CP062893 | ||
Organism | Escherichia coli O100:H21 strain Res13-Lact-ER07-18 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A075MDK3 |
Locus tag | IMP41_RS23520 | Protein ID | WP_000969988.1 |
Coordinates | 42350..42532 (+) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | - |
Locus tag | IMP41_RS23515 | Protein ID | WP_001324224.1 |
Coordinates | 42156..42353 (+) | Length | 66 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IMP41_RS23500 | 38436..39649 | + | 1214 | WP_085947772.1 | IS3 family transposase | - |
IMP41_RS23505 | 39659..40225 | - | 567 | Protein_34 | colicin V synthesis protein | - |
IMP41_RS23510 | 40200..41474 | - | 1275 | WP_195706930.1 | HlyD family secretion protein | - |
IMP41_RS23515 | 42156..42353 | + | 198 | WP_001324224.1 | toxin-antitoxin system protein | Antitoxin |
IMP41_RS23520 | 42350..42532 | + | 183 | WP_000969988.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
IMP41_RS23525 | 42631..42939 | + | 309 | WP_000377483.1 | hypothetical protein | - |
IMP41_RS23530 | 43499..44533 | + | 1035 | WP_001190234.1 | 3-deoxy-7-phosphoheptulonate synthase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | sitABCD | iroB / iroC / iroN / iroE / iroD / iutA / iucD / iucC / iucB / iucA | 1..99946 | 99946 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6931.07 Da Isoelectric Point: 4.5349
>T177181 WP_000969988.1 NZ_CP062893:42350-42532 [Escherichia coli O100:H21]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV
Download Length: 183 bp
>T177181 NZ_CP083273:2369996-2370103 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 66 a.a. Molecular weight: 7658.53 Da Isoelectric Point: 7.2046
>AT177181 WP_001324224.1 NZ_CP062893:42156-42353 [Escherichia coli O100:H21]
MDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRDEMSRKVAGK
MDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRDEMSRKVAGK
Download Length: 198 bp
>AT177181 NZ_CP083273:c2369949-2369883 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|