Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 42156..42532 Replicon plasmid unnamed973
Accession NZ_CP062893
Organism Escherichia coli O100:H21 strain Res13-Lact-ER07-18

Toxin (Protein)


Gene name parE Uniprot ID A0A075MDK3
Locus tag IMP41_RS23520 Protein ID WP_000969988.1
Coordinates 42350..42532 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag IMP41_RS23515 Protein ID WP_001324224.1
Coordinates 42156..42353 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP41_RS23500 38436..39649 + 1214 WP_085947772.1 IS3 family transposase -
IMP41_RS23505 39659..40225 - 567 Protein_34 colicin V synthesis protein -
IMP41_RS23510 40200..41474 - 1275 WP_195706930.1 HlyD family secretion protein -
IMP41_RS23515 42156..42353 + 198 WP_001324224.1 toxin-antitoxin system protein Antitoxin
IMP41_RS23520 42350..42532 + 183 WP_000969988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMP41_RS23525 42631..42939 + 309 WP_000377483.1 hypothetical protein -
IMP41_RS23530 43499..44533 + 1035 WP_001190234.1 3-deoxy-7-phosphoheptulonate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sitABCD iroB / iroC / iroN / iroE / iroD / iutA / iucD / iucC / iucB / iucA 1..99946 99946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6931.07 Da        Isoelectric Point: 4.5349

>T177181 WP_000969988.1 NZ_CP062893:42350-42532 [Escherichia coli O100:H21]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV

Download         Length: 183 bp

>T177181 NZ_CP083273:2369996-2370103 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7658.53 Da        Isoelectric Point: 7.2046

>AT177181 WP_001324224.1 NZ_CP062893:42156-42353 [Escherichia coli O100:H21]
MDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRDEMSRKVAGK

Download         Length: 198 bp

>AT177181 NZ_CP083273:c2369949-2369883 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A075MDK3

Antitoxin

Source ID Structure

References