Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 137022..137598 Replicon plasmid unnamednovel_0
Accession NZ_CP062888
Organism Escherichia coli strain Res13-Lact-PEA06-10

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag IMP66_RS24850 Protein ID WP_195686660.1
Coordinates 137341..137598 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag IMP66_RS24845 Protein ID WP_029488776.1
Coordinates 137022..137252 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP66_RS24825 132156..132962 - 807 WP_097423266.1 site-specific integrase -
IMP66_RS24830 132963..133268 - 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB -
IMP66_RS24835 133270..133488 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA -
IMP66_RS24840 134202..136823 + 2622 WP_023063774.1 ABC transporter -
IMP66_RS24845 137022..137252 + 231 WP_029488776.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IMP66_RS24850 137341..137598 + 258 WP_195686660.1 type II toxin-antitoxin system VapC family toxin Toxin
IMP66_RS24855 137754..138962 - 1209 WP_000198533.1 IS91 family transposase -
IMP66_RS24860 138943..139215 - 273 WP_000019163.1 hypothetical protein -
IMP66_RS24865 139334..139551 - 218 Protein_154 transposase -
IMP66_RS24870 139552..140082 - 531 WP_000348883.1 GNAT family N-acetyltransferase -
IMP66_RS24875 140086..140355 - 270 WP_001275013.1 DUF1778 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..141254 141254
- flank IS/Tn - - 137754..138962 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 8994.24 Da        Isoelectric Point: 7.8646

>T177147 WP_195686660.1 NZ_CP062888:137341-137598 [Escherichia coli]
VFSHRIVVSAITYSEMRFGASGPKASPRHVQLVDKFCPCLDAILSWDRAAVDGTTDIKVALRQAGTPIGQNDTAIAGPEA
GRIGN

Download         Length: 258 bp

>T177147 NZ_CP083259:753853-754062 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAAAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8808.91 Da        Isoelectric Point: 4.6286

>AT177147 WP_029488776.1 NZ_CP062888:137022-137252 [Escherichia coli]
MRTVSIVKNGNNRAIHLPRDLDFERVRELEIVREGDSIILRPVQPNWGSFAQLEKADPDFMAERENVVSDEGRFDL

Download         Length: 231 bp

>AT177147 NZ_CP083259:753548-753841 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAAAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CATTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References