Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3446963..3447581 Replicon chromosome
Accession NZ_CP062883
Organism Escherichia coli strain Res13-Lact-PEA06-10

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag IMP66_RS16645 Protein ID WP_001291435.1
Coordinates 3447363..3447581 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag IMP66_RS16640 Protein ID WP_000344800.1
Coordinates 3446963..3447337 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP66_RS16630 3442052..3443245 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IMP66_RS16635 3443268..3446417 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
IMP66_RS16640 3446963..3447337 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
IMP66_RS16645 3447363..3447581 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
IMP66_RS16650 3447753..3448304 + 552 WP_000102564.1 maltose O-acetyltransferase -
IMP66_RS16655 3448420..3448890 + 471 WP_000136192.1 YlaC family protein -
IMP66_RS16660 3449054..3450604 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
IMP66_RS16665 3450646..3450999 - 354 WP_000878140.1 DUF1428 domain-containing protein -
IMP66_RS16675 3451378..3451689 + 312 WP_000409911.1 MGMT family protein -
IMP66_RS16680 3451720..3452292 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T177129 WP_001291435.1 NZ_CP062883:3447363-3447581 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T177129 NZ_CP083182:4875-5162 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCACGATGTCTCTTTCGAAACGGCAAG
CCTTGTTTTTGAAGATCCACTAAGGATCTCAATCCAGGATAGACATACCGATGGTGAAGAACGTTGGCAGACCATTGGAA
AAGTAAAAGGCGTACTAATGCTACTAGTAGCCCACACCATCTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCTAGACAGGTAACTAAGGCGGAGCGAAATCAATATGAGCATGGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT177129 WP_000344800.1 NZ_CP062883:3446963-3447337 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT177129 NZ_CP083182:5149-5460 [Acinetobacter baumannii]
ATGAGCATGGTTAGATATACACGCAAAGAGCTGAATGAAAATTTCAGTAACAAGCAAGATGCTGAAATTGAACGCTTGCT
TGCTAAGGGAACAGTTCCTGACGATCAGCTAGATCTATCCGATATTCCTGAAATTACCGACTGGAGTAATGCTATTCGTC
ATGGGCAATTTTATCGTCCAGTGAAGCAACAAACTTCTGTTCGTCTTGATGCTGATGTACTTGCATGGTTAAAAGCACAA
GGAAAAGGGTATCAGACACGCATGAATAAAATTCTGCGTGAAGCAATGTTAAAAGATTTAAAAGATCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References