Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2366445..2368033 Replicon chromosome
Accession NZ_CP062883
Organism Escherichia coli strain Res13-Lact-PEA06-10

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag IMP66_RS11515 Protein ID WP_001125439.1
Coordinates 2366711..2368033 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IMP66_RS11510 Protein ID WP_001301023.1
Coordinates 2366445..2366711 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP66_RS11505 2362638..2366222 + 3585 Protein_2250 autotransporter barrel domain-containing lipoprotein -
IMP66_RS11510 2366445..2366711 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
IMP66_RS11515 2366711..2368033 + 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
IMP66_RS11520 2368345..2368553 + 209 Protein_2253 helix-turn-helix transcriptional regulator -
IMP66_RS11525 2368808..2370034 + 1227 Protein_2254 fimbrial biogenesis outer membrane usher protein -
IMP66_RS11530 2370048..2370578 + 531 WP_000876763.1 type 1 fimbrial protein -
IMP66_RS11535 2370591..2371094 + 504 WP_000825452.1 type 1 fimbrial protein -
IMP66_RS11540 2371153..2372067 + 915 WP_000520676.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2359466..2379253 19787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T177128 WP_001125439.1 NZ_CP062883:2366711-2368033 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T177128 NZ_CP083181:c2652475-2651819 [Acinetobacter baumannii]
ATGGTTGGACGTAATTATAGTGATGTACTCAATCCGCAAAAGGCATTGATTTGGCGTATTGTGCATCGTGATAATATTCC
GTGGATATTAGAAAATGGCTTACATAGCAGTAATAGTCCAACACAATGTGTAAATTGGGTTCAGATTGGCAGTCCAGAAC
TGATTGAGAAAAGACAACTGCATCCTGTTCCTGTAGGGAAAAAGGGTGTGCTAAGTGACTATATTCCATTTTATTTCACA
CCATTTTCACCTATGCTGCTGAATATAAAGAGTGGCCGTGGCGGTGTACGTCAGCGTACTAATGATGAAATTGTTATTTT
AGTTTCTAGTTTGTATCAGCTACAGCAGCAGCAAATTCCTTTTGTTTTTACAAATAGTCATGCCTATTACCAATGGGCTG
AATTCTATACAGATTTATCTAGCTTAAATGAGATCGATTGGTCAATATTACAGGCAAGAGATTTTAAAAGAGATATGGAT
GATCCTGCGAAGTTTGAACGTTATCAAGCCGAAGCGTTAGTTCATCAACACTGCCCAACAAAAGTATTGATTGGGGTGAT
ATGTTATACTGAAACAGTTAAAGCTCAAATAGAACAGTGGCTGCAACAAGCAGATGTTAATATTCCTGTGCATGTGAGAC
AAGGGGTGTATTTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT177128 WP_001301023.1 NZ_CP062883:2366445-2366711 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT177128 NZ_CP083181:c2651819-2650734 [Acinetobacter baumannii]
ATGATTCGTTATACAACAGGAAACTTATTAGATGCTCCTGTAGAAGCATTGGTAAATACCGTGAATACCGTTGGTGTAAT
GGGTAAAGGTATTGCTTTAATGTTTAAGGAGCGTTTTCCAAAAAACATGGCAGCTTATAGTCAAGCGTGCAAAGCTGGAC
AGGTTACAACTGGAAAAATGTTTGTGACTGAAACTAATGAGTTAATGGGCGCACGTTGGATTATTAACTTTCCAACTAAA
CAGCATTGGCGGGATAAATCCAAACTCCAATGGATTGAAGATGGTTTGCAGGATCTTAAAAAGTTCATCATTGATCATCA
AGTTAAATCTATTGCAATTCCACCATTAGGTGCGGGTAATGGTGGGTTAGAGTGGAGTCGTGTTAAATCAAAAATTGAGA
CAGAATTATCCGATTTAGAGTATGTGGATATTTTGATTTTTGAACCAACCACACAGTATCAAAACGTGGCAAAGAAAATA
GGTGTATCACAACTTACACCAGCACGAGCCATGATTGCAGAGTTAGTACGTCGTTATTGGGTATTGGGGATTGAATGTAG
TCTATTAGAAATCCAAAAACTGGCATGGTTTTTACAGCGAGTTATTGAGCAAAAACAATTACCAAATGAATTGAAGCTTA
ATTTTCAGGCGAACTATTATGGTCCTTATGCTTCTAATTTAGACCATTTGTTGAATGCAATGGATGGTAGCTATCTCAAA
TCGGACAAGCGAATTCCTGATTGTGACCCCTTAGATGTGATTTGGTTCAATGATCAGCAAAAAAGTAAAGTTCAAGGTTA
TCTGATTAGTGAAGCAAAAGAGTATATGGCTGCTGTAGAAGGAGCTGCAACATTGATAGAGGGTTTTGAATCACCATTTG
GTATGGAGCTTTTGGCAACAGTAGATTGGCTTATCTATAAGGAAGGTTATCAACCTAATGTTGAATCAATTCAAGAAGGG
TTAGCGAATTGGAGTGCAGGTGAGCGTTGGGCAAGACGGAAATCTGATTTATTCAAAGCAGAGCATATTCAATTTGCATT
ACAAAAATTAGATGGTTTTGCTTATTCTTATTCAGATGTAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References