Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 59505..60040 Replicon plasmid unnamed972
Accession NZ_CP062867
Organism Escherichia coli O39:H21 strain Res13-Lact-PEB08-01

Toxin (Protein)


Gene name relE Uniprot ID Q3YTD6
Locus tag IMP90_RS23765 Protein ID WP_000222766.1
Coordinates 59505..59792 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0VIP2
Locus tag IMP90_RS23770 Protein ID WP_001132900.1
Coordinates 59789..60040 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP90_RS23745 55167..55844 + 678 WP_001682408.1 IS66-like element accessory protein TnpA -
IMP90_RS23750 55844..56191 + 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -
IMP90_RS23755 56211..57782 + 1572 WP_000381395.1 IS66 family transposase -
IMP90_RS23760 58015..59228 + 1214 WP_162841971.1 IS3 family transposase -
IMP90_RS23765 59505..59792 - 288 WP_000222766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMP90_RS23770 59789..60040 - 252 WP_001132900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IMP90_RS23775 61006..61863 - 858 WP_000131010.1 incFII family plasmid replication initiator RepA -
IMP90_RS23780 61856..61930 - 75 WP_001365705.1 RepA leader peptide Tap -
IMP90_RS23785 62177..62425 - 249 WP_000083835.1 replication regulatory protein RepA -
IMP90_RS23790 62709..62915 - 207 WP_001553767.1 type I toxin-antitoxin system Hok family toxin -
- 62902..62963 + 62 NuclAT_2 - -
- 62902..62963 + 62 NuclAT_2 - -
- 62902..62963 + 62 NuclAT_2 - -
- 62902..62963 + 62 NuclAT_2 - -
IMP90_RS23795 63138..63520 - 383 Protein_56 hypothetical protein -
IMP90_RS23800 63623..64084 - 462 WP_000760078.1 thermonuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iroB / iroC / iroD / iroE / iroN / vat / iucA / iucB / iucC / iucD / iutA 1..155756 155756


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11147.23 Da        Isoelectric Point: 10.5832

>T176985 WP_000222766.1 NZ_CP062867:c59792-59505 [Escherichia coli O39:H21]
MTYTVKFRDDALKEWLKLDKTIQQQFVKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

>T176985 NZ_CP083036:2008822-2008924 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 4.0780

>AT176985 WP_001132900.1 NZ_CP062867:c60040-59789 [Escherichia coli O39:H21]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT176985 NZ_CP083036:c2008931-2008786 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDZ2

Antitoxin

Source ID Structure
AlphaFold DB V0VIP2

References