Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4074540..4075354 Replicon chromosome
Accession NZ_CP062863
Organism Escherichia coli strain Res13-Lact-PEB14-36

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag IMP96_RS20750 Protein ID WP_001054376.1
Coordinates 4074540..4074797 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID B7MMJ3
Locus tag IMP96_RS20755 Protein ID WP_001338189.1
Coordinates 4074809..4075354 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP96_RS20730 4069828..4070934 + 1107 WP_001299704.1 N-acetylneuraminate epimerase -
IMP96_RS20735 4070999..4071979 + 981 WP_061350442.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
IMP96_RS20740 4072562..4073802 - 1241 Protein_3820 DNA helicase -
IMP96_RS20745 4073918..4074163 + 246 Protein_3821 GNAT family N-acetyltransferase -
IMP96_RS20750 4074540..4074797 + 258 WP_001054376.1 hypothetical protein Toxin
IMP96_RS20755 4074809..4075354 + 546 WP_001338189.1 N-acetyltransferase Antitoxin
IMP96_RS20760 4075410..4076156 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
IMP96_RS20765 4076325..4076543 + 219 Protein_3825 hypothetical protein -
IMP96_RS20770 4076581..4076697 + 117 Protein_3826 VOC family protein -
IMP96_RS20775 4076942..4078063 + 1122 WP_000010829.1 M42 family metallopeptidase -
IMP96_RS20780 4078060..4078338 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
IMP96_RS20785 4078350..4079663 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4067037..4083578 16541


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T176946 WP_001054376.1 NZ_CP062863:4074540-4074797 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T176946 NZ_CP083021:343175-343543 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19986.92 Da        Isoelectric Point: 6.3277

>AT176946 WP_001338189.1 NZ_CP062863:4074809-4075354 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT176946 NZ_CP083021:342957-343178 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2KXJ3

References