176929

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 867545..868199 Replicon chromosome
Accession NZ_CP062863
Organism Escherichia coli strain Res13-Lact-PEB14-36

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag IMP96_RS05400 Protein ID WP_000244777.1
Coordinates 867792..868199 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag IMP96_RS05395 Protein ID WP_000354046.1
Coordinates 867545..867811 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP96_RS05370 862714..863457 + 744 WP_000951964.1 SDR family oxidoreductase -
IMP96_RS05375 863514..864947 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
IMP96_RS05380 864992..865303 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
IMP96_RS05385 865467..866126 + 660 WP_000250274.1 hemolysin III family protein -
IMP96_RS05390 866322..867302 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
IMP96_RS05395 867545..867811 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
IMP96_RS05400 867792..868199 + 408 WP_000244777.1 toxin CptA Toxin
IMP96_RS05405 868239..868760 - 522 WP_001055874.1 flavodoxin FldB -
IMP96_RS05410 868872..869768 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
IMP96_RS05415 869793..870503 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IMP96_RS05420 870509..872242 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T176929 WP_000244777.1 NZ_CP062863:867792-868199 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T176929 NZ_CP083011:c3971455-3971138 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT176929 WP_000354046.1 NZ_CP062863:867545-867811 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT176929 NZ_CP083011:c3971145-3970858 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References