Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 75372..75919 Replicon plasmid unnamednovel_0
Accession NZ_CP062843
Organism Escherichia coli strain Res13-Lact-PER02-33

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag IMQ20_RS24505 Protein ID WP_000969996.1
Coordinates 75372..75653 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A2H4TKU7
Locus tag IMQ20_RS24510 Protein ID WP_000079923.1
Coordinates 75650..75919 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ20_RS24475 70899..71090 - 192 WP_157895655.1 hypothetical protein -
IMQ20_RS24480 71587..72588 + 1002 WP_029488840.1 DUF2219 family protein -
IMQ20_RS24485 72663..73568 - 906 Protein_76 IS3 family transposase -
IMQ20_RS24490 73578..74729 - 1152 WP_195686650.1 IS30-like element IS30 family transposase -
IMQ20_RS24495 74797..75099 - 303 Protein_78 transposase -
IMQ20_RS24500 75135..75332 - 198 Protein_79 3'-5' exonuclease -
IMQ20_RS24505 75372..75653 - 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMQ20_RS24510 75650..75919 - 270 WP_000079923.1 hypothetical protein Antitoxin
IMQ20_RS24515 76838..77694 - 857 Protein_82 incFII family plasmid replication initiator RepA -
IMQ20_RS24520 77687..77761 - 75 WP_001365705.1 RepA leader peptide Tap -
IMQ20_RS24525 78008..78256 - 249 WP_000083838.1 replication regulatory protein RepA -
IMQ20_RS24530 78540..78746 - 207 WP_032339099.1 type I toxin-antitoxin system Hok family toxin -
- 78733..78794 + 62 NuclAT_0 - -
- 78733..78794 + 62 NuclAT_0 - -
- 78733..78794 + 62 NuclAT_0 - -
- 78733..78794 + 62 NuclAT_0 - -
IMQ20_RS24535 78969..79352 - 384 Protein_86 hypothetical protein -
IMQ20_RS24540 79470..79916 - 447 WP_032339098.1 thermonuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..141262 141262
- inside IScluster/Tn - - 72663..86490 13827


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T176838 WP_000969996.1 NZ_CP062843:c75653-75372 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T176838 NZ_CP082975:1899003-1899105 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10196.52 Da        Isoelectric Point: 7.2050

>AT176838 WP_000079923.1 NZ_CP062843:c75919-75650 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVEQQHNTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT176838 NZ_CP082975:c1899112-1898967 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A2H4TKU7

References