Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 56428..57029 Replicon plasmid unnamed1009
Accession NZ_CP062833
Organism Escherichia coli strain Res13-Lact-PER04-33

Toxin (Protein)


Gene name doc Uniprot ID U9Z1Q0
Locus tag IMQ22_RS23110 Protein ID WP_001216047.1
Coordinates 56649..57029 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag IMQ22_RS23105 Protein ID WP_001190712.1
Coordinates 56428..56649 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ22_RS23070 51703..51891 + 189 WP_000797279.1 hypothetical protein -
IMQ22_RS23075 51893..52071 + 179 Protein_64 hypothetical protein -
IMQ22_RS23080 52405..53415 + 1011 WP_042198315.1 hypothetical protein -
IMQ22_RS23085 53412..53774 + 363 WP_001261543.1 hypothetical protein -
IMQ22_RS23090 54850..55206 - 357 WP_001062545.1 hypothetical protein -
IMQ22_RS23095 55207..55791 - 585 WP_042198310.1 hypothetical protein -
IMQ22_RS23100 55966..56355 + 390 WP_000506730.1 DNA repair protein -
IMQ22_RS23105 56428..56649 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IMQ22_RS23110 56649..57029 + 381 WP_001216047.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
IMQ22_RS23115 57034..57213 + 180 WP_000113018.1 hypothetical protein -
IMQ22_RS23120 57241..58284 + 1044 WP_195686630.1 DUF968 domain-containing protein -
IMQ22_RS23125 58373..58825 + 453 WP_001326849.1 late promoter-activating protein -
IMQ22_RS23130 58911..60104 + 1194 WP_047649469.1 hypothetical protein -
IMQ22_RS23135 60104..61588 + 1485 WP_000124159.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE / aac(3)-VIa / ant(3'')-Ia htpB 1..109181 109181


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13574.27 Da        Isoelectric Point: 5.1514

>T176796 WP_001216047.1 NZ_CP062833:56649-57029 [Escherichia coli]
MRHISPEELVALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T176796 NZ_CP082948:c1480528-1480268 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT176796 WP_001190712.1 NZ_CP062833:56428-56649 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT176796 NZ_CP082948:c1480751-1480530 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9Z1Q0

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References