Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 910246..910900 Replicon chromosome
Accession NZ_CP062832
Organism Escherichia coli strain Res13-Lact-PER04-33

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag IMQ22_RS04385 Protein ID WP_000244777.1
Coordinates 910493..910900 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag IMQ22_RS04380 Protein ID WP_000354046.1
Coordinates 910246..910512 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ22_RS04355 905415..906158 + 744 WP_000951962.1 SDR family oxidoreductase -
IMQ22_RS04360 906215..907648 - 1434 WP_032200738.1 6-phospho-beta-glucosidase BglA -
IMQ22_RS04365 907693..908004 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
IMQ22_RS04370 908168..908827 + 660 WP_000250274.1 hemolysin III family protein -
IMQ22_RS04375 909023..910003 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
IMQ22_RS04380 910246..910512 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
IMQ22_RS04385 910493..910900 + 408 WP_000244777.1 toxin CptA Toxin
IMQ22_RS04390 910940..911461 - 522 WP_001055874.1 flavodoxin FldB -
IMQ22_RS04395 911573..912469 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
IMQ22_RS04400 912494..913204 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IMQ22_RS04405 913210..914943 + 1734 WP_061359363.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T176778 WP_000244777.1 NZ_CP062832:910493-910900 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T176778 NZ_CP082930:c154117-153701 [Salmonella enterica subsp. enterica serovar London]
GTGAAGAAAATGTATATGCCCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCCGAAGCGGTGCTGAAGCGCCT
GGAGCAAGCGGTGCTGCGCGGCCACCGTATCGTGGTCTCGGCCATCACTTACTCCGAGATGCGCTTCGGTGCCACCGGCC
CAAAGGCCTCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGATGCGACCATGGAGATTAAGGTGGCACTGCGCCTCGCCGGGACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCGGCGCCATTCTGGTGACGAATAATGTGAGGGAGTTTGAGCGGGTGCCGGGCCTTGTACTGG
AAGACTGGGCGAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT176778 WP_000354046.1 NZ_CP062832:910246-910512 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT176778 NZ_CP082930:c154344-154114 [Salmonella enterica subsp. enterica serovar London]
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTCG
AAAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGATGTTGTCACCGATGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References