Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 137030..137606 Replicon plasmid unnamednovel_0
Accession NZ_CP062831
Organism Escherichia coli strain Res13-Lact-PER12-33-A

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag IMQ30_RS24815 Protein ID WP_195686660.1
Coordinates 137349..137606 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag IMQ30_RS24810 Protein ID WP_029488776.1
Coordinates 137030..137260 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ30_RS24790 132164..132970 - 807 WP_097423266.1 site-specific integrase -
IMQ30_RS24795 132971..133276 - 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB -
IMQ30_RS24800 133278..133496 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA -
IMQ30_RS24805 134210..136831 + 2622 WP_023063774.1 ABC transporter -
IMQ30_RS24810 137030..137260 + 231 WP_029488776.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IMQ30_RS24815 137349..137606 + 258 WP_195686660.1 type II toxin-antitoxin system VapC family toxin Toxin
IMQ30_RS24820 137762..138970 - 1209 WP_000198533.1 IS91 family transposase -
IMQ30_RS24825 138951..139223 - 273 WP_000019163.1 hypothetical protein -
IMQ30_RS24830 139342..139559 - 218 Protein_152 transposase -
IMQ30_RS24835 139560..140090 - 531 WP_000348883.1 GNAT family N-acetyltransferase -
IMQ30_RS24840 140094..140363 - 270 WP_001275013.1 DUF1778 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..141262 141262
- flank IS/Tn - - 137762..138970 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 8994.24 Da        Isoelectric Point: 7.8646

>T176773 WP_195686660.1 NZ_CP062831:137349-137606 [Escherichia coli]
VFSHRIVVSAITYSEMRFGASGPKASPRHVQLVDKFCPCLDAILSWDRAAVDGTTDIKVALRQAGTPIGQNDTAIAGPEA
GRIGN

Download         Length: 258 bp

>T176773 NZ_CP082929:c4169908-4169417 [Salmonella enterica subsp. enterica serovar London]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8808.91 Da        Isoelectric Point: 4.6286

>AT176773 WP_029488776.1 NZ_CP062831:137030-137260 [Escherichia coli]
MRTVSIVKNGNNRAIHLPRDLDFERVRELEIVREGDSIILRPVQPNWGSFAQLEKADPDFMAERENVVSDEGRFDL

Download         Length: 231 bp

>AT176773 NZ_CP082929:c4170198-4169905 [Salmonella enterica subsp. enterica serovar London]
ATGTCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTCGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCACCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References