Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 98046..98647 Replicon plasmid unnamed1009
Accession NZ_CP062827
Organism Escherichia coli strain Res13-Lact-PER12-33-A

Toxin (Protein)


Gene name doc Uniprot ID U9Z1Q0
Locus tag IMQ30_RS23280 Protein ID WP_001216047.1
Coordinates 98267..98647 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag IMQ30_RS23275 Protein ID WP_001190712.1
Coordinates 98046..98267 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ30_RS23240 93321..93509 + 189 WP_000797279.1 hypothetical protein -
IMQ30_RS23245 93511..93689 + 179 Protein_94 hypothetical protein -
IMQ30_RS23250 94023..95033 + 1011 WP_042198315.1 hypothetical protein -
IMQ30_RS23255 95030..95392 + 363 WP_001261543.1 hypothetical protein -
IMQ30_RS23260 96468..96824 - 357 WP_001062545.1 hypothetical protein -
IMQ30_RS23265 96825..97409 - 585 WP_042198310.1 hypothetical protein -
IMQ30_RS23270 97584..97973 + 390 WP_000506730.1 DNA repair protein -
IMQ30_RS23275 98046..98267 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IMQ30_RS23280 98267..98647 + 381 WP_001216047.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
IMQ30_RS23285 98652..98831 + 180 WP_000113018.1 hypothetical protein -
IMQ30_RS23290 98859..99902 + 1044 WP_195686630.1 DUF968 domain-containing protein -
IMQ30_RS23295 99991..100443 + 453 WP_001326849.1 late promoter-activating protein -
IMQ30_RS23300 100529..101722 + 1194 WP_047649469.1 hypothetical protein -
IMQ30_RS23305 101722..103206 + 1485 WP_000124159.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE / aac(3)-VIa / ant(3'')-Ia - 1..117229 117229


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13574.27 Da        Isoelectric Point: 5.1514

>T176760 WP_001216047.1 NZ_CP062827:98267-98647 [Escherichia coli]
MRHISPEELVALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T176760 NZ_CP082928:c683640-683071 [Pseudomonas fulva]
ATGTTCAAGCCGCAATTGATCACCCTGCAGCGCGGTGCCCTGCGCATCGAACCGTTGCTCGATGGCGATATTCCGGCGCT
GGTCAGCCTGGCCGAAGCCAACCGCGAGGAACTGCTCTACATGAACGGTACCCAGCGCCTGGATTGGTATCGCCTGGCCC
TGCAAGAGCAGCGCGAGGAGCGCGCCTTGCCCTTGGTGATTCGCCTCGCCGACCAGATCGTCGGCACCACGCGGTTCGCC
GACTTCATGCCGACCCTGCCGGCCGTGGAAATCGGCTGGACCTGGCTGGACGCCGCCCAGCACGGCACGGGCCTCAATAA
CATGGTCAAGTACCTGATGCTGCGCCACGCCTTCGAGAGTTGGCAGATGGTGCGCGTGCAGCTGAAAACCGCGGCCAGCA
ACCTGCGCTCCCAGCGCGCCATCGAAAAGCTCGGCGCGGTTCGCGAAGGGCTGCTGCGCAACCATCGCCGCCTGGCCGAC
GGGCGCCTCGACGACACCGTGCTGTACAGCATCACCGACCAGGAGTGGCCGCTGGTCAAGGCCGGGCTGGAGGCACGCTT
CGGCGTGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT176760 WP_001190712.1 NZ_CP062827:98046-98267 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT176760 NZ_CP082928:c683067-682225 [Pseudomonas fulva]
ATGCCTGCCGGCGAGCGCATCCGCTTTTGGGAAAGCCCCGCGCTGGCCGGCGTGGAGCTGCTGCAGGCGCGCTATATCAA
GCAGCGCTTCACCCCCCATGTACATGAAGGCTTCGTGTTCACCGTGATCGAGGGCGGCGCCCAGCGCTTTCGCCATCGTG
GCGCCGACCACCTGGCGCCGATTGGCAGCATGGTGTTGATCAACCCCGACGAAGTGCACACCGGCTCGGCCGCCCATGAG
CAGGGCTGGTTATACCGGGCGTTCTACCCGGCTCCGGCACAGGTCAGCGGTGTGCTCGACGAGCTCGGGCTGGCGCAACG
CGGCTTGCCGTCGTTCGCCGCCAGCGTGCTGCAGGATATGCAGTTGCACCAGGCGTTCGGCCAGCTGCATCGCCTGCTCG
ACAGTGACGCCAGCGTGCTGCAGCAACAGACCGCCTGGCGCGAGACGCTGCTGATGCTGTTCCAGCGGCATGCCGGGGTC
AGGCAGGCAGCCGTGCCCGGCCAGGAGCCCCGTGCCGTGCGCCTGGCCAAGGAACTCTTGGTCGCGCGCCTGGGCGAGCC
ACCGACACTGGAAGCGTTGGCGGCTGCGGTGAACCTCTCGCCGTTTCATTTCGCCCGGGTGTTTCGCCGCGCCACCGGCC
TGCCGCCCCATGCCTGGCTGCAACAGCGGCGCCTGGAACAGGCGCGGGCGTTGCTGCGCGATGGCTGCGCGCCGCTGAGC
GTGGCGCTGCAACTGGGCTTCGCCGACCAGAGCCACCTGACGCGGCAGTTCAAGCAGGTGTATGGCGTGGGGCCCGGCGA
GTACCGCAAGGCCTGCCATCACAGCCCTGTAGCCTGTGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9Z1Q0

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References