Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3340996..3341627 Replicon chromosome
Accession NZ_CP062824
Organism Escherichia coli O167:H26 strain Res13-Lact-PER13-34

Toxin (Protein)


Gene name hicA Uniprot ID L4J012
Locus tag IMQ31_RS15700 Protein ID WP_001260301.1
Coordinates 3340996..3341271 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag IMQ31_RS15705 Protein ID WP_000593555.1
Coordinates 3341268..3341627 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ31_RS15685 3336000..3337067 + 1068 WP_033870452.1 HlyD family efflux transporter periplasmic adaptor subunit -
IMQ31_RS15690 3337064..3339799 + 2736 WP_001600636.1 ribosome-associated ATPase/putative transporter RbbA -
IMQ31_RS15695 3339799..3340923 + 1125 WP_001318088.1 ABC transporter permease -
IMQ31_RS15700 3340996..3341271 + 276 WP_001260301.1 type II toxin-antitoxin system HicA family toxin Toxin
IMQ31_RS15705 3341268..3341627 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IMQ31_RS15710 3341677..3342537 - 861 WP_001600635.1 class II aldolase -
IMQ31_RS15715 3342568..3342837 - 270 WP_000949583.1 HPr family phosphocarrier protein -
IMQ31_RS15720 3342827..3344335 - 1509 WP_024229777.1 carbohydrate kinase -
IMQ31_RS15725 3344328..3345686 - 1359 WP_001306345.1 PTS galactitol transporter subunit IIC -
IMQ31_RS15730 3345763..3346044 - 282 WP_085459110.1 PTS sugar transporter subunit IIB -
IMQ31_RS15735 3346041..3346514 - 474 WP_001306344.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3334012..3348590 14578


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.87 Da        Isoelectric Point: 10.6128

>T176729 WP_001260301.1 NZ_CP062824:3340996-3341271 [Escherichia coli O167:H26]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T176729 NZ_CP082918:287741-288091 [Sutcliffiella horikoshii]
TTGATTGTCAAACGCGGTGACGTTTATTTTGCTGATTTATCCCCGGTTGTTGGGTCTGAGCAAGGAGGCGTTCGACCAGT
ACTTGTCATCCAAAATGATATCGGAAATCGTTTTAGCCCGACCGTTATAGTAGCTGCCATTACTGCTCAAATCCAAAAAG
CCAAACTCCCAACACATGTAGAGATCGATGCGAAGCGTTATGGTTTTGAACGTGACTCTGTTATCCTGCTCGAACAAATT
CGAACAATTGATAAACAAAGATTAACGGACAAAATTACTCATCTTGACGAAGAGATGATGGACAAAGTGGATGAGGCGCT
TCAAATAAGCTTAGGACTTATTGACTTTTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT176729 WP_000593555.1 NZ_CP062824:3341268-3341627 [Escherichia coli O167:H26]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT176729 NZ_CP082918:287455-287736 [Sutcliffiella horikoshii]
GTGTCTGAATCCAGCGCAACAACTGAAATCTTGATTCGATTACCTCAAAACTTAGTGTCGGAATTAGATGGTTTGGTAAA
ACAAGAAAACGGCAATCGAAACGAATTAATCTTTCAAGCAACAAAGATGTATCTTCGCGAGCGCAAAAAGCGTCAGATTC
GCGAGTCCATGAGACGTGGCTACATGGAAATGTCTAAAATCAATCTAAACATTGCATCTGAAGCTTTTTTGGCTGAATAT
GAGGCGGAGCATACGGTTGAACGCTTAGTAAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L4J012

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References