Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3202384..3202996 Replicon chromosome
Accession NZ_CP062824
Organism Escherichia coli O167:H26 strain Res13-Lact-PER13-34

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag IMQ31_RS15110 Protein ID WP_000833473.1
Coordinates 3202384..3202569 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1V3VHB3
Locus tag IMQ31_RS15115 Protein ID WP_000499746.1
Coordinates 3202586..3202996 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ31_RS15095 3197899..3199050 + 1152 WP_000741501.1 L-threonine dehydrogenase -
IMQ31_RS15100 3199251..3200789 + 1539 WP_001521595.1 aldehyde dehydrogenase AldB -
IMQ31_RS15105 3200830..3201909 - 1080 WP_000061477.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
IMQ31_RS15110 3202384..3202569 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
IMQ31_RS15115 3202586..3202996 + 411 WP_000499746.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IMQ31_RS15120 3203068..3205032 - 1965 WP_064226479.1 glycoside hydrolase family 127 protein -
IMQ31_RS15125 3205043..3206443 - 1401 WP_085459126.1 MFS transporter -
IMQ31_RS15130 3206669..3207484 + 816 WP_000891838.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T176728 WP_000833473.1 NZ_CP062824:3202384-3202569 [Escherichia coli O167:H26]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

>T176728 NZ_CP082917:c15058-14753 [Salmonella enterica subsp. enterica serovar Newlands]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15290.22 Da        Isoelectric Point: 4.5486

>AT176728 WP_000499746.1 NZ_CP062824:3202586-3202996 [Escherichia coli O167:H26]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDYAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp

>AT176728 NZ_CP082917:c15278-15060 [Salmonella enterica subsp. enterica serovar Newlands]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A1V3VHB3

References