Detailed information of TA system TA176725

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 2474986..2475581
• Replicon: chromosome
• Accession: NZ_CP062824
• Organism: Escherichia coli O167:H26 strain Res13-Lact-PER13-34

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: IMQ31_RS11790
• Protein ID: WP_000239581.1
• Coordinates: 2474986..2475336 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: IMQ31_RS11795
• Protein ID: WP_001223213.1
• Coordinates: 2475330..2475581 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMQ31_RS11770	2470440..2471462	-	1023	WP_001383778.1	ABC transporter permease	-
IMQ31_RS11775	2471476..2472978	-	1503	WP_001095668.1	sugar ABC transporter ATP-binding protein	-
IMQ31_RS11780	2473111..2474067	-	957	WP_000265933.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
IMQ31_RS11785	2474377..2474907	+	531	WP_000055075.1	inorganic diphosphatase	-
IMQ31_RS11790	2474986..2475336	-	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
IMQ31_RS11795	2475330..2475581	-	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
IMQ31_RS11800	2475793..2476134	-	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
IMQ31_RS11805	2476137..2479916	-	3780	WP_085458436.1	autotransporter assembly complex protein TamB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T176725 WP_000239581.1 NZ_CP062824:c2475336-2474986 [Escherichia coli O167:H26]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T176725 NZ_CP082916:3090401-3090814 [Salmonella enterica subsp. enterica serovar Newlands]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT176725 WP_001223213.1 NZ_CP062824:c2475581-2475330 [Escherichia coli O167:H26]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT176725 NZ_CP082916:3090154-3090420 [Salmonella enterica subsp. enterica serovar Newlands]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: V0SXT4

Antitoxin

• AlphaFold DB: L4JJX7