Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2463515..2464037 Replicon chromosome
Accession NZ_CP062824
Organism Escherichia coli O167:H26 strain Res13-Lact-PER13-34

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag IMQ31_RS11730 Protein ID WP_001105433.1
Coordinates 2463515..2463805 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D8WJ36
Locus tag IMQ31_RS11735 Protein ID WP_000212718.1
Coordinates 2463795..2464037 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ31_RS11715 2458683..2460338 + 1656 WP_059341582.1 alpha,alpha-phosphotrehalase -
IMQ31_RS11720 2460732..2462870 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
IMQ31_RS11725 2463050..2463514 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IMQ31_RS11730 2463515..2463805 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMQ31_RS11735 2463795..2464037 - 243 WP_000212718.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IMQ31_RS11740 2464229..2464615 - 387 WP_001232253.1 cytochrome b562 -
IMQ31_RS11745 2464798..2466150 - 1353 WP_001162171.1 metalloprotease PmbA -
IMQ31_RS11750 2466244..2466795 + 552 WP_000166270.1 ribosome-associated protein -
IMQ31_RS11755 2466878..2468251 - 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-66)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T176724 WP_001105433.1 NZ_CP062824:c2463805-2463515 [Escherichia coli O167:H26]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T176724 NZ_CP082916:2624074-2624349 [Salmonella enterica subsp. enterica serovar Newlands]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9174.63 Da        Isoelectric Point: 5.1369

>AT176724 WP_000212718.1 NZ_CP062824:c2464037-2463795 [Escherichia coli O167:H26]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLAYPQEAIKVRLDEL

Download         Length: 243 bp

>AT176724 NZ_CP082916:2623811-2624071 [Salmonella enterica subsp. enterica serovar Newlands]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8WJ36

References