Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2919691..2920339 Replicon chromosome
Accession NZ_CP062821
Organism Providencia rettgeri strain Res13-Sevr-LER2-35

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag IMQ36_RS13720 Protein ID WP_094961724.1
Coordinates 2919691..2919876 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IMQ36_RS13725 Protein ID WP_094961723.1
Coordinates 2919926..2920339 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ36_RS13700 2915565..2916653 - 1089 WP_102137564.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -
IMQ36_RS13705 2916656..2917516 - 861 WP_102137563.1 sulfate/thiosulfate ABC transporter permease CysW -
IMQ36_RS13710 2917516..2918346 - 831 WP_102137562.1 sulfate/thiosulfate ABC transporter permease CysT -
IMQ36_RS13715 2918346..2919368 - 1023 WP_102137561.1 sulfate ABC transporter substrate-binding protein -
IMQ36_RS13720 2919691..2919876 + 186 WP_094961724.1 type II toxin-antitoxin system HicA family toxin Toxin
IMQ36_RS13725 2919926..2920339 + 414 WP_094961723.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IMQ36_RS13730 2920405..2921304 - 900 WP_195697433.1 Dyp-type peroxidase -
IMQ36_RS13735 2921547..2922152 - 606 WP_195697434.1 RpoE-regulated lipoprotein -
IMQ36_RS13740 2922244..2922675 - 432 WP_004264887.1 GNAT family acetyltransferase -
IMQ36_RS13745 2922812..2923729 + 918 WP_195697435.1 oxygen-dependent coproporphyrinogen oxidase -
IMQ36_RS13750 2923888..2925024 + 1137 WP_195697436.1 M4 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6992.20 Da        Isoelectric Point: 11.0146

>T176704 WP_094961724.1 NZ_CP062821:2919691-2919876 [Providencia rettgeri]
VQSSELINILQKNGWKLERIKGSHHQFSHPHFSIVITVPHPQKDLKIGTLNHILKAAKLKH

Download         Length: 186 bp

>T176704 NZ_CP082909:5084483-5084767 [Endozoicomonas sp. 4G]
ATGACTTATGAGCTGATCTTCAAGGAAGAAGCTCTGAAAGAGTGGCGCCAGCTTGACCAGAGCCTTCGGGATCAGTTCAG
GAAAAAACTTGATGAACGACGACGATCGCCTAAAGTGCAATCGGCTCGACTCAGAGATATAAAGAACTGTTACAAGATAA
AATTACGTTCTTCCGGCTTCCGGCTGGTTTATGAAGTGCGGGACAAAGAGATTGTGATTGTTGTTATTGCTGTGGGCAAA
CGCGATCGCCAGAAAGTTTACCGGGAAGCGCAGAGGCGTCTTTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15362.31 Da        Isoelectric Point: 4.6719

>AT176704 WP_094961723.1 NZ_CP062821:2919926-2920339 [Providencia rettgeri]
MLYTAFIEIDNDGSASGWFPDIEGCTFAGSNIEEAYAEAKSAIDAHFELLSEKGFEIPLSKSQQTLLNPIQPEYAHGIWL
FVDVDMDKYDGRTERINITLPHRLLHRIDALVKVNPEYGSRSGFIAAAARKELKKTD

Download         Length: 414 bp

>AT176704 NZ_CP082909:5084239-5084493 [Endozoicomonas sp. 4G]
ATGCCAAATGTTCATCCCGTACTGGCCGATATGGCGACCAGTATCAGCGAATTCAAAAAAAATCCCATGGCCGTCATTCA
TCAGGGAGGGGGCCAGCCGGTGGCTGTTCTGAACCGCAATGAACCTGCTTTTTACTGCGTACCCTCTGTCGTCTGGGAAG
CGGTACTGGATCAGCTGGAAGACATCGAACTGGCCAGGCTGGTTGAGGAGCGCAAAAACCAGAAAGAAATCCCGGTAGAC
CTCGATGACTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References