Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 137027..137603 Replicon plasmid unnamednovel_0
Accession NZ_CP062820
Organism Escherichia coli strain Res13-Sevr-PER06-05-b-A

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag IMQ58_RS24840 Protein ID WP_195686660.1
Coordinates 137346..137603 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag IMQ58_RS24835 Protein ID WP_029488776.1
Coordinates 137027..137257 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ58_RS24815 132161..132967 - 807 WP_097423266.1 site-specific integrase -
IMQ58_RS24820 132968..133273 - 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB -
IMQ58_RS24825 133275..133493 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA -
IMQ58_RS24830 134207..136828 + 2622 WP_023063774.1 ABC transporter -
IMQ58_RS24835 137027..137257 + 231 WP_029488776.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IMQ58_RS24840 137346..137603 + 258 WP_195686660.1 type II toxin-antitoxin system VapC family toxin Toxin
IMQ58_RS24845 137759..138967 - 1209 WP_000198533.1 IS91 family transposase -
IMQ58_RS24850 138948..139220 - 273 WP_000019163.1 hypothetical protein -
IMQ58_RS24855 139339..139556 - 218 Protein_154 transposase -
IMQ58_RS24860 139557..140087 - 531 WP_000348883.1 GNAT family N-acetyltransferase -
IMQ58_RS24865 140091..140360 - 270 WP_001275013.1 DUF1778 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..141259 141259
- flank IS/Tn - - 137759..138967 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 8994.24 Da        Isoelectric Point: 7.8646

>T176699 WP_195686660.1 NZ_CP062820:137346-137603 [Escherichia coli]
VFSHRIVVSAITYSEMRFGASGPKASPRHVQLVDKFCPCLDAILSWDRAAVDGTTDIKVALRQAGTPIGQNDTAIAGPEA
GRIGN

Download         Length: 258 bp

>T176699 NZ_CP082909:c2627937-2627647 [Endozoicomonas sp. 4G]
ATGAGTTATGAGCTTGAATTTAAAAAATCAGCGCTGAAGGAATGGAAAAAACTTAATCCAGCGGTAAGGGATCAGTTCAA
GAAAGTTCTGGAAAGAAGATTGGTCGATCCACATGTGCCTTCTGCGCAGGTATCAGGAGCTCCAAACATGTATAAGATCA
AGCTCAGACAATTGGGTTACAGGCTAATTTATTCTGTGTCAGAAAAAACCATTACTGTGAGAGTTCTTGCTATTGGCAAG
AGAGATAAAAACGAAGTTTATCAGGTTGCTTTATCTCGACTTTTGCAGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8808.91 Da        Isoelectric Point: 4.6286

>AT176699 WP_029488776.1 NZ_CP062820:137027-137257 [Escherichia coli]
MRTVSIVKNGNNRAIHLPRDLDFERVRELEIVREGDSIILRPVQPNWGSFAQLEKADPDFMAERENVVSDEGRFDL

Download         Length: 231 bp

>AT176699 NZ_CP082909:c2628175-2627927 [Endozoicomonas sp. 4G]
ATGGCTAGCCAAATATTAACTGATACTGCTGCGAGCATTTCTGAATTGAAGGCAAATCCTATGAAAGTTGTTGCTAGTGG
TGAGGGATTACCTGTCGCGGTACTGAACAGAAACGAACCAGCCTTTTACTGTGTTCCTGCCAAAGCTTATGAAGCTATGA
TGGAACTCATTGAGGATTTGGAATTATTAGAAATTGTCAAACAAAGGGAAAATGAAGAATCTGTAAAGGTTTCGCTTGAT
GAGTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References