Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 132968..133493 Replicon plasmid unnamednovel_0
Accession NZ_CP062820
Organism Escherichia coli strain Res13-Sevr-PER06-05-b-A

Toxin (Protein)


Gene name ccdB Uniprot ID V0SSI5
Locus tag IMQ58_RS24820 Protein ID WP_001159868.1
Coordinates 132968..133273 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1PPD8
Locus tag IMQ58_RS24825 Protein ID WP_000813634.1
Coordinates 133275..133493 (-) Length 73 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ58_RS24795 128800..129444 - 645 WP_029488797.1 replication initiation protein RepE -
IMQ58_RS24800 129472..130377 - 906 Protein_143 IS3 family transposase -
IMQ58_RS24805 130442..131593 + 1152 WP_195686658.1 IS30-like element IS30 family transposase -
IMQ58_RS24810 131606..131908 - 303 Protein_145 transposase -
IMQ58_RS24815 132161..132967 - 807 WP_097423266.1 site-specific integrase -
IMQ58_RS24820 132968..133273 - 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB Toxin
IMQ58_RS24825 133275..133493 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
IMQ58_RS24830 134207..136828 + 2622 WP_023063774.1 ABC transporter -
IMQ58_RS24835 137027..137257 + 231 WP_029488776.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
IMQ58_RS24840 137346..137603 + 258 WP_195686660.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..141259 141259
- flank IS/Tn - - 137759..138967 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-100)

Antitoxin

(2-72)


Sequences


Toxin        


Download         Length: 102 a.a.        Molecular weight: 11706.51 Da        Isoelectric Point: 6.4674

>T176698 WP_001159868.1 NZ_CP062820:c133273-132968 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T176698 NZ_CP082909:c2542981-2542409 [Endozoicomonas sp. 4G]
ATGGCTTCTCAATTTACTGCTGTTTTTGATGCCTGTGTCCTTTATCCCTCGGTGTTAAGAGACGTACTGTTAAGGTTGGC
GATAACAGACACTTTTCGCGCCAGGTGGACTGACAAAATTCATGATGAGTGGACTCGCAATCTGAAAGCCAATCGTCCAG
ATATCGATGAAAACTACTTGAACAAAACGCGACAGTTGATGAATGTTCATGTCCGGGATGCATTGGTTGAAGGCTTCGAG
CATCTGATTGATTCTGTTCAATTACCTGATCAGGATGACCGGCATGTTGTTGCAGCAGCAATTTCCGCCAACGCTGATGT
TATAGTCACATATAATCTGAAAGACTTTCCTGATGAAGCCCTTGCCCCGTATGAGCTTCAGGCTATTCATCCTGACAGCT
TTATTCATGACCTGATCGACCTGCACCCGGCAGAATTCATTGGTGTCATTCGTTCAGCGAGAGCTGCCTTAAAAAATCCA
CCACTAACGGTTGATGAGTACCTGGGTAGATTGAGAAAGCAAAGACTGCCGGAAACGGTCACCTGGCTAGAGTCAATGAA
GCTCATTTTGTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8372.34 Da        Isoelectric Point: 4.7405

>AT176698 WP_000813634.1 NZ_CP062820:c133493-133275 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT176698 NZ_CP082909:c2543439-2542981 [Endozoicomonas sp. 4G]
ATGACTACAAAAGACAAACTGACCTTGCCCACCGCCGAAGAGATTGCGATTGCACAAGAGTGCAGCCGGGAGATTTCAGC
CTTTCTTGAGACGGGTTCTGAATCTCAGCAAATTGATATCAGCTCTAAGGATGGGGAAAAGCACGCGTTGTCGATTCCTA
CCAGAGCATTGAGTCTGCTGGTTGATATTCTGGCGCAACTTGGACAGGGTAATGCGGTAAAAATCATCCCGATCCATGCG
GAACTGACCACTCAGCAAGCCGCTGATATTCTCAATGTTTCCCGTCCTTATCTGGTCAGAATGCTGGATGAAGGGGAAAT
TCCTCATCACAAGGTTGGTCGGCATCGTAGAGTCCGTTATCAGGATTTAATGGATTACAAAGCGGCTATAGACGGTAAAC
GACTCTCAGCTTTGGATGAGTTGTCAGCTCTCTCGCAGATGAACGATCCGGAGTATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4VUB
PDB 2VUB
PDB 7EPI
PDB 7EPG
PDB 3VUB
PDB 1X75
PDB 1VUB
PDB 7EPJ
PDB 3HPW
PDB 3G7Z


Antitoxin

Source ID Structure
PDB 3TCJ
PDB 2H3A
PDB 2ADN
PDB 2ADL
PDB 3HPW
PDB 2H3C
PDB 3G7Z
AlphaFold DB A0A829CQY2

References