Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 15153..15754 Replicon plasmid unnamed1009
Accession NZ_CP062816
Organism Escherichia coli strain Res13-Sevr-PER06-05-b-A

Toxin (Protein)


Gene name doc Uniprot ID U9Z1Q0
Locus tag IMQ58_RS22900 Protein ID WP_001216047.1
Coordinates 15374..15754 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag IMQ58_RS22895 Protein ID WP_001190712.1
Coordinates 15153..15374 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ58_RS22860 10428..10616 + 189 WP_000797279.1 hypothetical protein -
IMQ58_RS22865 10618..10796 + 179 Protein_18 hypothetical protein -
IMQ58_RS22870 11130..12140 + 1011 WP_042198315.1 hypothetical protein -
IMQ58_RS22875 12137..12499 + 363 WP_001261543.1 hypothetical protein -
IMQ58_RS22880 13575..13931 - 357 WP_001062545.1 hypothetical protein -
IMQ58_RS22885 13932..14516 - 585 WP_042198310.1 hypothetical protein -
IMQ58_RS22890 14691..15080 + 390 WP_000506730.1 DNA repair protein -
IMQ58_RS22895 15153..15374 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IMQ58_RS22900 15374..15754 + 381 WP_001216047.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
IMQ58_RS22905 15759..15938 + 180 WP_000113018.1 hypothetical protein -
IMQ58_RS22910 15966..17009 + 1044 WP_195686630.1 DUF968 domain-containing protein -
IMQ58_RS22915 17098..17550 + 453 WP_001326849.1 late promoter-activating protein -
IMQ58_RS22920 17636..18829 + 1194 WP_047649469.1 hypothetical protein -
IMQ58_RS22925 18829..20313 + 1485 WP_000124159.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE / aac(3)-VIa / ant(3'')-Ia htpB 1..117229 117229


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13574.27 Da        Isoelectric Point: 5.1514

>T176686 WP_001216047.1 NZ_CP062816:15374-15754 [Escherichia coli]
MRHISPEELVALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T176686 NZ_CP082909:c437181-436897 [Endozoicomonas sp. 4G]
GTGCATAAACTGGAGTGGTTAAGCCTTGCTCGTAACGACCTCTTGGCCATTGTCGATTACATTTCCGATGATAATCCAAA
GGCGGCTCTCCGACTAAAAGATGACATTCAGGCCAAAGCTGAAAAGCTTATGGATTTTCCCAAAATAGGTAAGGTAGGCC
GGATTGAAGGAACAAGGGAATTAGTGGCCTTTGGAAACTACATTATTGTCTACAGGGAAAGTGGCACCATTATTCGGATA
CTTCGCATTTTACACGCTGCACAGCAGTGGCCATCTTCTAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT176686 WP_001190712.1 NZ_CP062816:15153-15374 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT176686 NZ_CP082909:c437464-437174 [Endozoicomonas sp. 4G]
ATGGCTCATACATCAATGCTGCACGTTCGCGTGGATGACACCTTAAAAAAAGAAGCCACTGAAAAGCTGGCCAACTTCGG
CTTAACCCTATCTGATGCAGTTCGGATCCTGTTAACCCGGATAACCAAAGAAGGTGGCTTGCCCGTCGGCCTCACCAGTG
ATCCTGAAGCACACGATGCCTGGTTCCGGGAGCGGGTTAAAGAAGCCCTGAACTCTGAAGAGGTTTTGCCTCATAGCCAG
GTTATGGATGACGTCCAGGCCTTGATCGAAAGGAAAAAACGACGTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9Z1Q0

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References