Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3444917..3445535 Replicon chromosome
Accession NZ_CP062815
Organism Escherichia coli strain Res13-Sevr-PER06-05-b-A

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag IMQ58_RS16635 Protein ID WP_001291435.1
Coordinates 3445317..3445535 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag IMQ58_RS16630 Protein ID WP_000344800.1
Coordinates 3444917..3445291 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ58_RS16620 3440006..3441199 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IMQ58_RS16625 3441222..3444371 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
IMQ58_RS16630 3444917..3445291 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
IMQ58_RS16635 3445317..3445535 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
IMQ58_RS16640 3445707..3446258 + 552 WP_000102564.1 maltose O-acetyltransferase -
IMQ58_RS16645 3446374..3446844 + 471 WP_000136192.1 YlaC family protein -
IMQ58_RS16650 3447008..3448558 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
IMQ58_RS16655 3448600..3448953 - 354 WP_000878140.1 DUF1428 domain-containing protein -
IMQ58_RS16665 3449332..3449643 + 312 WP_000409911.1 MGMT family protein -
IMQ58_RS16670 3449674..3450246 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T176681 WP_001291435.1 NZ_CP062815:3445317-3445535 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T176681 NZ_CP082904:c2919060-2918749 [Mixta hanseatica]
ATGCACGTTATTTCCAAAGAACCATTTGAGCAAGCGGCACGGCTCTTTCCAAATGATGCCACAGCAATAAAGGCACTATA
TCGACTGGTTCGCGAAACCGATTTTAAATCGCCTGATGAACTACGTGCTGCAGTGCCAAGTCTCGATAATTTTAAGTATC
GCAACAAATGGTGGGTTTTAGATGTTGGGGGTAATCACTTGAGAGTGATCGTTTACATCAATTTTGTGAATAAGCGCTTC
TACGTTAAGCACATCGCTACCCACACTGAATACGATAAGCTGACTCGCTACTATCGGGAGAATAAAGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT176681 WP_000344800.1 NZ_CP062815:3444917-3445291 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT176681 NZ_CP082904:c2918752-2918333 [Mixta hanseatica]
ATGATCGCCGACACCACAAAAGCTATTGAAGCAACGAAACAGCTGGTAGCTGCTGTCCCTTTTCTCGGGAGCAGTGTTTC
TGAGAAGGACTATCGTGACGCGCTGGCGTTGGTAAACTACCTGATCGACAATGACGACGAAAATCCACTGATTGACTTTC
TGACGGTAAAAATCGCTGCTTATGAAGATAACAGCGAGCATTTTGCAGCGTTCAACAAGGCGGTAGAAGAAATGCCGGTG
GGGGTTGCGCTACTGCGCACGCTGATTGATCAGCATAAGCTCTCTTACTCCGATCTGAAGCAAGAGATTGGTTCCAAATC
ATTGGTGAGCCAAATCCTTTCCGGGCAGCGTTCTTTAACTATTTCTCACATTAAAGCGCTTTCGGTGAGGTTCGGCGTGA
AGCCTCAATGGTTCCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References