Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 910106..910760 Replicon chromosome
Accession NZ_CP062815
Organism Escherichia coli strain Res13-Sevr-PER06-05-b-A

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag IMQ58_RS04390 Protein ID WP_000244777.1
Coordinates 910353..910760 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag IMQ58_RS04385 Protein ID WP_000354046.1
Coordinates 910106..910372 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ58_RS04360 905275..906018 + 744 WP_000951962.1 SDR family oxidoreductase -
IMQ58_RS04365 906075..907508 - 1434 WP_032200738.1 6-phospho-beta-glucosidase BglA -
IMQ58_RS04370 907553..907864 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
IMQ58_RS04375 908028..908687 + 660 WP_000250274.1 hemolysin III family protein -
IMQ58_RS04380 908883..909863 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
IMQ58_RS04385 910106..910372 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
IMQ58_RS04390 910353..910760 + 408 WP_000244777.1 toxin CptA Toxin
IMQ58_RS04395 910800..911321 - 522 WP_001055874.1 flavodoxin FldB -
IMQ58_RS04400 911433..912329 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
IMQ58_RS04405 912354..913064 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IMQ58_RS04410 913070..914803 + 1734 WP_061359363.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T176668 WP_000244777.1 NZ_CP062815:910353-910760 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T176668 NZ_CP082893:2435-2722 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGATATACTAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT176668 WP_000354046.1 NZ_CP062815:910106-910372 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT176668 NZ_CP082893:2709-3023 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References