176657

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4505533..4506030 Replicon chromosome
Accession NZ_CP062811
Organism Escherichia coli strain Res13-Sevr-PER07-33

Toxin (Protein)


Gene name ghoT Uniprot ID A0A163EQM5
Locus tag IMQ59_RS21555 Protein ID WP_001672275.1
Coordinates 4505533..4505706 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag IMQ59_RS21560 Protein ID WP_000398619.1
Coordinates 4505734..4506030 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ59_RS21545 4502203..4503660 + 1458 WP_000856824.1 dipeptide/tripeptide permease DtpC -
IMQ59_RS21550 4503897..4505414 + 1518 WP_001295074.1 lysine--tRNA ligase -
IMQ59_RS21555 4505533..4505706 - 174 WP_001672275.1 type V toxin-antitoxin system toxin GhoT Toxin
IMQ59_RS21560 4505734..4506030 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
IMQ59_RS21565 4506257..4506529 - 273 WP_000405647.1 N-acetyltransferase -
IMQ59_RS21570 4506541..4506771 - 231 WP_000371704.1 (4Fe-4S)-binding protein -
IMQ59_RS21575 4506952..4508583 + 1632 WP_001216477.1 sensor histidine kinase -
IMQ59_RS21580 4508580..4509299 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6569.09 Da        Isoelectric Point: 10.2288

>T176657 WP_001672275.1 NZ_CP062811:c4505706-4505533 [Escherichia coli]
MALFSKILIFYVIGVNISFIIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T176657 NZ_CP082883:1052350-1053240 [Burkholderia dolosa]
ATGACCGTCATCGAAAAGCGCGAACGCGCAGCGGCTTTCGCCGCGCTGCTCGAGCAGTTTCCGGAGCAGCGCTGCGCGGC
CGGTGCGGCCGGCACGATCGGCTATCGCGAGGCCGGCGCGCAGCAAGCGGACCGTGCGCTGCCCGTCGTGCTGCTGCACG
GAATCGGCTCGGGCGCCGCATCGTGGGTGCGTCAGCTCGATGCGCTCGGCGCGGTGCGCCGCGTGCTCGCGTGGGACGCG
CCCGGCTACGGCGCATCGACGCCGGTGCGCGCGGCATCGCCGGTCGCCGCCGATTACGCGGCCGCGCTGGATGCGTGGCT
TGACGCGCTCGGCATCGAGCGCTGCGTGGTGGTCGGCCATTCGCTCGGCGCGATCGTCGCGGGCGGCATGGTGAGCGCGA
TGCCGGCGCGAATCGCCGGGTTGCTGCTGATCTCGCCGGCGGGCGGCTACGGCAGCGCGAGCGCCGATACGCGCAACGCG
CGCCGCGACGCGCGGCTCGCGATGCTCGCGGCGCTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAATATGCTGTC
CGGCTTCGCGAGCGACGATGCGCGTGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGACGGCTACGCGCAGGCGA
CGCATCTGCTCGCGAACGCCGATCTGGCGGCCGACGTCGCCGGTTTCGCCGGTCATGCGGCGGTGGCCGTCGGTGCAAAC
GACGCGATCACGCCGCCCGCTGCATGCGAACGGATCGCGGCGGCGCTCGGCGTCGAACTGCAGGTGGTTCCGCAGGCCGG
CCACGCCGGTTACGTCGAAGCGCCGGCCATCTATTCCGCGCTGATCGACGCGTTCTGCCGATCGTGCGACACGCAGCGGA
GGCCCGCATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT176657 WP_000398619.1 NZ_CP062811:c4506030-4505734 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT176657 NZ_CP082883:1053237-1054094 [Burkholderia dolosa]
ATGAGCGCGCCGCTGCAACGCCAGGCAGCCGACGACGCGAAGGCCGATGCCGGCTACGTCGTGCCGGGGCTCGAGCGCGG
GCTGCGGATTCTCGCGGAGTTTTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGTATTCCGC
GCACGACGGTGTTTCGCCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGACCGGAACTACCGG
CTCGGCATCGCGGTGCTGCGGCTCGGCTTCGAGTATCTGAGCTCGCTCGAGCTGACCGATCTCGGGCTGCCCGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGC
AAAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGGCTGCCCGCGCATGCGACGACGCACGGTCAC
GTGCTGATGGGCGACCTGTCGCTGCAGGAGCTGTACGCGCTGTATCCGGAGCGCACGCTGAACCGGATGACGAGCGCGAC
GCCGGAGACGGTCGATGCGCTGTACGAAGCGATCCGCGAAGACGCACGGCGCGGCTACGGGATCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTCGTCACGGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGCCCCGAAATCGACGCGACGCTGATCGCGGACGGACTGATCGACAAGGTGCGGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTCATGAAGGCTTTGGGACTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A163EQM5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References