Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4410159..4410754 Replicon chromosome
Accession NZ_CP062811
Organism Escherichia coli strain Res13-Sevr-PER07-33

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag IMQ59_RS21070 Protein ID WP_000239579.1
Coordinates 4410159..4410509 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag IMQ59_RS21075 Protein ID WP_001223208.1
Coordinates 4410503..4410754 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ59_RS21050 4405605..4406627 - 1023 WP_001297255.1 ABC transporter permease -
IMQ59_RS21055 4406641..4408143 - 1503 WP_021574891.1 sugar ABC transporter ATP-binding protein -
IMQ59_RS21060 4408283..4409239 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
IMQ59_RS21065 4409549..4410079 + 531 WP_000055075.1 inorganic diphosphatase -
IMQ59_RS21070 4410159..4410509 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
IMQ59_RS21075 4410503..4410754 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
IMQ59_RS21080 4410966..4411307 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
IMQ59_RS21085 4411310..4415089 - 3780 WP_001672306.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T176656 WP_000239579.1 NZ_CP062811:c4410509-4410159 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T176656 NZ_CP082883:c809956-809357 [Burkholderia dolosa]
ATGACTCCCGACACGATTCACGCACGACTGGATTTTCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCG
CACGTCGAGCGGACGCGCCGAAAGCACGGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTGGCGTTCGCCGACGCGC
TGCCCGGCGTCGACACGCTGAAGCTGCTGAAGCTGTGCGTCGTGCACGATCTCGGCGAGGCGCTGCACGGCGACATTCCG
GCGATCGAGCAAGCCGCGCATCCGGACAAGAGCGCGCACGAGCGCAACGATCTGCTGACGCTGACGGCGGCGCTCGACGG
CCCGCTGCGCGACGAGATCGTCGCGCTGTGGGACGAATATGAAGCGGTCGCGACGCCGGAAGCCCGCGCCGCGAAGGCGC
TCGACAAGCTCGAGACGATCCTGCAGCACAACCAGGGCGACAACCCGCCCGATTTCGATTACGCGTTCAATCTCGACTAT
GGCCGGCGCTACACGGATGCGGCGCCGCTGTTCATCGCGATCCGCGCGGTCGTCGATGCGGACACGCAACGCAGAATCGA
CGCACGCGCGCACACCGCTTGCACGAAGGGTTCCGCATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT176656 WP_001223208.1 NZ_CP062811:c4410754-4410503 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT176656 NZ_CP082883:c810607-810050 [Burkholderia dolosa]
ATGGCAGCGCCCGCACTTCATACGCCACCGCTGGGCCCGCAACTGAAGCGCTGGCGCGTGCTGCACCGGATAAAGCAGAG
CCACGCGGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCATCCAGCAGATGTCCGCCGACG
AGCGCGCGACGGCGGAACGTCTGCTCGCCGCGCATCTCGATTCCGCCGGCGACCATGCACTCGCGCGGCTGATCGCGGAC
AGCGCGGGCCGCATGCATCTGGTGTGCGACCTCACGCATCGTCTGCTCGCGTGCTCGCCGCTGCGTGCGGCCGAGTTCTC
GCAGCCGCTGCCGCTGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGAGATCGTCCGCATGGAATCGGCGCTCG
ACACGCTCGGCTGGCACGACCGCGCGGGGCCGCCGAGCGTCGAGTTCGACACCGGCGCAAACGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCCGATGCCGCTGGACGCGGATGACGCTGTCGGACGGATCGGCGGTGCGTCTGGTCGAAACGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References