Detailed information of TA system TA176655

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 4332617..4333164
• Replicon: chromosome
• Accession: NZ_CP062811
• Organism: Escherichia coli strain Res13-Sevr-PER07-33

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IMQ59_RS20685
• Protein ID: WP_001402901.1
• Coordinates: 4332883..4333164 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: IMQ59_RS20680
• Protein ID: WP_024245977.1
• Coordinates: 4332617..4332886 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMQ59_RS20665	4328970..4330328	-	1359	WP_000823253.1	esterase-like activity of phytase family protein	-
IMQ59_RS20670	4330854..4331444	-	591	WP_021574913.1	hypothetical protein	-
IMQ59_RS20675	4332024..4332428	+	405	WP_021574912.1	hypothetical protein	-
IMQ59_RS20680	4332617..4332886	+	270	WP_024245977.1	hypothetical protein	Antitoxin
IMQ59_RS20685	4332883..4333164	+	282	WP_001402901.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IMQ59_RS20690	4333222..4333353	+	132	Protein_4053	IS3 family transposase	-
IMQ59_RS20695	4333691..4333948	-	258	WP_021574909.1	hypothetical protein	-
IMQ59_RS20700	4334286..4334390	-	105	Protein_4055	IS3 family transposase	-
IMQ59_RS20705	4334623..4334688	+	66	Protein_4056	omptin family outer membrane protease	-
IMQ59_RS20710	4334708..4335405	-	698	Protein_4057	IS1 family transposase	-
IMQ59_RS20715	4335697..4336218	+	522	WP_001283626.1	RNA polymerase sigma factor FecI	-
IMQ59_RS20720	4336215..4337168	+	954	WP_021574908.1	fec operon regulator FecR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	4321498..4334917	13419

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10875.53 Da
• Isoelectric Point: 8.4615

>T176655 WP_001402901.1 NZ_CP062811:4332883-4333164 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASSLAGQPYKGRNGRVEGARELVIHPHFVLVYEVDSQWGKV
YILRVLHTTQKWP

Nucleotide

• Length: 282 bp

>T176655 NZ_CP082880:c5946-5263 [Campylobacter coli]
ATGATTGATAAAGTTTTGAAATTTTTAGATGATGGTATTCCTAAAAATGATTTTGATAGACAACTTTTAGCTTCTAATTT
AGTAGGCGCAACAAATTTAATAGAGTTAAATAAAAAAGAAAGAATAATAACTCTACAAGCCGCTAAAAAATTAGAGCTTA
ATCCAATTAAAGGCAATTTTGACTATCAACACTTAAAAGATATACATAAAGCACTTTTTAAAGATGTTTATACTTGGGCT
GGAAAAGATAGAATGGAAGTAGGTTTGCATGGAAATTTTGGAAAATATGCACCAAATGGAACAATTACTAATTTTGTTCC
TGGAAAAGATTTAAATGTAACCGCTCAACAAATTTTTACTTGGCTTAAAGAAGACAATTACTTAACAAATTCAAAAGATC
TTAACGATTTTGCAAAGAACTTAGCCGAATTTGCTAGAAACCTAAATGCTTTGCACCCCTTTAGAGAAGGTAACGGCAGA
ACTCAAAGAATATTTTTAAATGAATTGGCTAAAAATGCAGGTTATAAACTTGATTTAAATTTAATACCAAAAGATAAAAT
GATAATGGCATCTGTAGAAGCTTCACAATTGAAATTAGGAAAACTTGAAGCCATAATTAAAACCAATCTAAAAAGCTTTA
GACAAAACTTAGATTTAGAGCAAAATAAAGGAATATCATTGTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10262.62 Da
• Isoelectric Point: 7.2057

>AT176655 WP_024245977.1 NZ_CP062811:4332617-4332886 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESPAAAWRD
EMSRKVAGK

Nucleotide

• Length: 270 bp

>AT176655 NZ_CP082880:c6181-5939 [Campylobacter coli]
ATGCAAAAACAATATCCCGAAGTGTATAGCTTAGAAGAAAGCCTTGCAATACTTAAAAAATATAAAGATGATTTAACTAA
AGAGCAATATGAGCAAAATAAATCTATTATTTGTGGATTTGCTATTGAGAATATGTTTGCAAATGAAGAAGACATTATAA
ATCTCATAAAAGTAGATAAACAAGAAAAAACACCTGATGAAATAATCGCCGAATATAAAAAAGAGTGGGGTGTAAATGAT
TGA