Detailed information of TA system TA176654

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4294841..4295661
• Replicon: chromosome
• Accession: NZ_CP062811
• Organism: Escherichia coli strain Res13-Sevr-PER07-33

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: IMQ59_RS20465
• Protein ID: WP_001054376.1
• Coordinates: 4294841..4295098 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: IMQ59_RS20470
• Protein ID: WP_001519303.1
• Coordinates: 4295110..4295661 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMQ59_RS20445	4290127..4291233	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
IMQ59_RS20450	4291298..4292278	+	981	WP_021574932.1	transposase	-
IMQ59_RS20455	4292861..4294102	-	1242	Protein_4006	DNA helicase	-
IMQ59_RS20460	4294165..4294464	+	300	WP_001765420.1	GNAT family N-acetyltransferase	-
IMQ59_RS20465	4294841..4295098	+	258	WP_001054376.1	hypothetical protein	Toxin
IMQ59_RS20470	4295110..4295661	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
IMQ59_RS20475	4295713..4296459	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
IMQ59_RS20480	4296586..4296846	+	261	WP_000084876.1	hypothetical protein	-
IMQ59_RS20485	4296884..4297000	+	117	Protein_4012	VOC family protein	-
IMQ59_RS20490	4297245..4298366	+	1122	WP_000010833.1	M42 family metallopeptidase	-
IMQ59_RS20495	4298363..4298641	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
IMQ59_RS20500	4298653..4299966	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T176654 WP_001054376.1 NZ_CP062811:4294841-4295098 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T176654 NZ_CP082863:2082440-2083765 [Cupriavidus pauculus]
ATGGGACGACGCGCGCAACGGCGCAGACTCGGCGTATGGATGAACGGTTGGCGCGCGGGCGTCTGGGAGCAGGGCGCCGA
TGGCGAGGCGTTTGCCTACGACGAAGACTGGATGGCCAGCCCGCAGGGCCGACCGCTCTCGCTTTCGCTGCCATTCCGTG
CCGACAATGCGCCGTACCGCGGCAGCATCGTGACTGATTATTTCGACAACCTGCTGCCCGACAGCGATGCCATCCGGCGG
CGTCTGGCATTGCGCCATCGCACGCAAGGCACCGGCCCGTTCGATCTGCTGGCCGCGCTGGGCCGCGATTGCGTAGGGGC
GCTGCAATTGCTGCCGGACGACACCGTGCCGGAGGGCCTGCACCGGATCGAGGGAACCGTGGTCGGCGAAGCCGCCATCG
CGCGCCTGTTGCGCGACACCACGCGCAACACGGCGGTGCTGGGACAGCCCGACGACAGCGGCGATCTGCGCCTGTCGATT
GCCGGTGCGCAGGAAAAGACCGCGCTGCTGTATCGAAACGGCAAGTGGCTGCTGCCGCATGGCAGCACGCCCACCACGCA
TATCCTGAAGCTGCCGTTGGGATTGGTCGGCAACATGCGCGCCGACATGCGCACTTCGGTAGAGAACGAATGGCTCTGCG
CGCAACTGGTCGGGCATTTCGGATTGCCGATCGCGCGGTGCGACATCGCCAGATTCGAGGACCAGAAAGTGCTGGTGGTG
GAACGCTTCGACCGCCGGCTGGCGCCGGACGGCAAATGGATCGTGCGGTTGCCGCAGGAGGATTTCTGCCAGGCGCTGGG
CATTTCGCCGCTATCGAAATACCAGGCCGATGGCGGCCCCGGCATCGGCGACATCATGGCGGTGCTGGCCGGCTCCGAGG
CGCCGGCCCACGACCGGCGCAATTTCTTTGCCACGCAGGTGTTGTTCTGGATGCTGGCGGCCACGGACGGCCACGCCAAG
AACTTCAGCCTGTCGATCGGTCCCGGTGGCCGTTATTGGTCCACGCCGCTGTACGACGTGCTGTCCGCCTTTCCGATCAT
GGGGCGAGGCGCCAGCCAGCTTGCGCCGCAGAAGGCGCGCATGGCAATGGCGGTGAGAGGCAGCCAGAACCACTATCGCA
TCGCTGAAATCATGCGGCGGCACTGGCTGGATCAGGGACGCCAGGCAGGCTTGCCGGCCGAGGAGGTGGAAACCGTGCTG
GCCGCGCTGAAAGGCGCCGTGGAACACGCCATCGCGATGGCCACCGCACAGTTGCCCGCCGACTTTCCGGCCGATGTGGC
CGACCGTGTCTTCAAGGGACTTCGGGCGCAGGCGCGCAAGCTCTGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT176654 WP_001519303.1 NZ_CP062811:4295110-4295661 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT176654 NZ_CP082863:2082162-2082440 [Cupriavidus pauculus]
ATGGCCGCCACCTATCCGATCCGCATCCTTAGCCAGTTACGCCCAGTCCTGCAGGGCTTACGCAAGTCTCGCGGCCTGAC
GCAGGCCGCGCTTGCAGCCAGACTGGGGGTGAGCCAGCAAAGCTATGCCCGCCTGGAAGCGAACCCGGGCCGCGCCAGCA
TGGCCCGCGTGCTCGCGGCCCTGCAGGCACTGGAAGTGGATCTGGCGCTGACGCCGCGCGGCGATACTTCCGCCACGGCA
CCCCGCCCGAAAAAAGCCAAACAGAAAGAGGACTGGTAA

Structures

Toxin

• AlphaFold DB: S1PA82