Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2364663..2365189 | Replicon | chromosome |
| Accession | NZ_CP062811 | ||
| Organism | Escherichia coli strain Res13-Sevr-PER07-33 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | IMQ59_RS11380 | Protein ID | WP_000323025.1 |
| Coordinates | 2364902..2365189 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | IMQ59_RS11375 | Protein ID | WP_000534858.1 |
| Coordinates | 2364663..2364902 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IMQ59_RS11340 | 2359849..2360076 | + | 228 | WP_000476993.1 | transcriptional regulator | - |
| IMQ59_RS11345 | 2360060..2360581 | + | 522 | WP_000705349.1 | hypothetical protein | - |
| IMQ59_RS11350 | 2360562..2361527 | + | 966 | WP_000054504.1 | hypothetical protein | - |
| IMQ59_RS11355 | 2361568..2361987 | + | 420 | WP_001151196.1 | DUF977 family protein | - |
| IMQ59_RS11360 | 2362021..2363361 | + | 1341 | WP_000589012.1 | ISNCY family transposase | - |
| IMQ59_RS11365 | 2363798..2364130 | - | 333 | WP_001317460.1 | FlxA-like family protein | - |
| IMQ59_RS11370 | 2364333..2364638 | - | 306 | WP_071527819.1 | hypothetical protein | - |
| IMQ59_RS11375 | 2364663..2364902 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| IMQ59_RS11380 | 2364902..2365189 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| IMQ59_RS11385 | 2365261..2365416 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| IMQ59_RS11390 | 2365633..2365884 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| IMQ59_RS11395 | 2365951..2366229 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| IMQ59_RS11400 | 2366231..2367280 | + | 1050 | WP_021574611.1 | DUF968 domain-containing protein | - |
| IMQ59_RS11405 | 2367294..2368046 | + | 753 | WP_001047135.1 | antitermination protein | - |
| IMQ59_RS11410 | 2368324..2368413 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| IMQ59_RS11415 | 2368468..2368680 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| IMQ59_RS11420 | 2368981..2369196 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| IMQ59_RS11425 | 2369950..2370165 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | sodB / fimA / espR1 / rhs/PAAR / vgrG/tssI | 2260492..2580198 | 319706 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T176645 WP_000323025.1 NZ_CP062811:2364902-2365189 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T176645 NZ_CP082857:1426748-1427086 [Haemophilus aegyptius]
GTGAAATTATCATTTATTGAATTACCGCCCTTTGAGCGTTACAGAAAAGCACATTTATCTGATGATGAATATAGGGCTTT
CCAGAATGAGCTATTAGAAAACCCTGAAAAGGGAGACGTGATACAAAATGCTGGTGGCTTGCGGAAAATTAGGATTGCCG
ATAGTGAAAGAAATAAAGGGAAACGAGGTGGCGCACGAGTGATTTATTACTATCTCATACGTAAATCGCAGATATTACTC
GTTACCGCTTACAGTAAAAACAGATGCGAAGATTTAACCACAGAGCAATATAAAATTTTAGCTAAACTGGTGAAAGAGAT
AGAGGAGCTAGAGCAATGA
GTGAAATTATCATTTATTGAATTACCGCCCTTTGAGCGTTACAGAAAAGCACATTTATCTGATGATGAATATAGGGCTTT
CCAGAATGAGCTATTAGAAAACCCTGAAAAGGGAGACGTGATACAAAATGCTGGTGGCTTGCGGAAAATTAGGATTGCCG
ATAGTGAAAGAAATAAAGGGAAACGAGGTGGCGCACGAGTGATTTATTACTATCTCATACGTAAATCGCAGATATTACTC
GTTACCGCTTACAGTAAAAACAGATGCGAAGATTTAACCACAGAGCAATATAAAATTTTAGCTAAACTGGTGAAAGAGAT
AGAGGAGCTAGAGCAATGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT176645 WP_000534858.1 NZ_CP062811:2364663-2364902 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT176645 NZ_CP082857:1427083-1427391 [Haemophilus aegyptius]
ATGAGTAAATTATTTGATGAGCTTATAGAAGGGCTAAATGCCTATAAAGACTTTACACAGGGGAAAATAACGCTCAGAGT
AGAGACGCGTGAACGAATTGAACCTGCAAGCATTACAGCAGAGGAAGTGAAAGCAATTAGAGAGAAATTAAACCTTTCTC
AAGCCGTTTTTGCGCAGAAGTTACGAACTAGTGTAAGAACCTATCAAGGTTGGGAGCAAGGGAAAACCAAACCTAGCGCA
CACGCCTCCTTATTGTTGCGCATGGTGGATAAAGCCCCGCAAACCTTTGAGCTCATCGCAGGGATATAA
ATGAGTAAATTATTTGATGAGCTTATAGAAGGGCTAAATGCCTATAAAGACTTTACACAGGGGAAAATAACGCTCAGAGT
AGAGACGCGTGAACGAATTGAACCTGCAAGCATTACAGCAGAGGAAGTGAAAGCAATTAGAGAGAAATTAAACCTTTCTC
AAGCCGTTTTTGCGCAGAAGTTACGAACTAGTGTAAGAACCTATCAAGGTTGGGAGCAAGGGAAAACCAAACCTAGCGCA
CACGCCTCCTTATTGTTGCGCATGGTGGATAAAGCCCCGCAAACCTTTGAGCTCATCGCAGGGATATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|