Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 903783..904437 Replicon chromosome
Accession NZ_CP062811
Organism Escherichia coli strain Res13-Sevr-PER07-33

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag IMQ59_RS04315 Protein ID WP_000244777.1
Coordinates 904030..904437 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag IMQ59_RS04310 Protein ID WP_000354046.1
Coordinates 903783..904049 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ59_RS04290 899871..901304 - 1434 WP_001362278.1 6-phospho-beta-glucosidase BglA -
IMQ59_RS04295 901349..901660 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
IMQ59_RS04300 901824..902483 + 660 WP_000250274.1 hemolysin III family protein -
IMQ59_RS04305 902560..903540 - 981 WP_001625883.1 tRNA-modifying protein YgfZ -
IMQ59_RS04310 903783..904049 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
IMQ59_RS04315 904030..904437 + 408 WP_000244777.1 toxin CptA Toxin
IMQ59_RS04320 904477..904998 - 522 WP_001055874.1 flavodoxin FldB -
IMQ59_RS04325 905110..906006 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
IMQ59_RS04330 906031..906741 + 711 WP_001625881.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IMQ59_RS04335 906747..908480 + 1734 WP_000813198.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T176635 WP_000244777.1 NZ_CP062811:904030-904437 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T176635 NZ_CP082855:118613-118933 [Legionella anisa]
ATGAATCGTGGTGATGTATATTGGGTAAACCTCGACCCTACTACAGGCTCTGAAATCAACAAACTCAGACCTTGCGTTTT
AGTTGGAGCAACACCGATTAATCAAGCAAGACGCACTGTTGTCGTCGTTCCTCTTTCAAGCTCTGCTACAGCCAGACCAC
CAATTACCATCACTGTTTCTTGTCTTGGCAAACAAGTTACCGCAGTTTGTGATCAAATAAGAACGATTGATAAAAGTCGT
TTAAAAAAAGTGGCAGGAAACCTTTCAGATAAAGATTTAAATGCCTTGGATGATGGGTTACGACAAGTTTTATGCCTTTG
A

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT176635 WP_000354046.1 NZ_CP062811:903783-904049 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT176635 NZ_CP082855:118390-118626 [Legionella anisa]
ATGATGAATAAAGTTTTAATATCAATACCCGATCAAATCGCTTCTAGAATGAGAGCAGCAATACCTCAGCGACAACGCAG
CAAGGTGATTGCTCATCTTATTGAAAAAGAAATTGAACGACGTGAAAAAGCGCTCTATGAATGCGCTTTAGCTGTTGAAA
ATGATCATGGTTTACAAAATGAAATGAACGATTGGGATATAACGGTTCAAGATGGATTAACTGATGAATCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References