Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 393238..393992 Replicon chromosome
Accession NZ_CP062811
Organism Escherichia coli strain Res13-Sevr-PER07-33

Toxin (Protein)


Gene name ataT Uniprot ID A0A1Y2XJ17
Locus tag IMQ59_RS01740 Protein ID WP_001626109.1
Coordinates 393238..393723 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q8X700
Locus tag IMQ59_RS01745 Protein ID WP_000801912.1
Coordinates 393714..393992 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ59_RS01720 388406..389164 + 759 WP_000815096.1 DeoR/GlpR family transcriptional regulator -
IMQ59_RS01725 389146..390743 - 1598 Protein_342 DNA-binding transcriptional regulator RtcR -
IMQ59_RS01730 390930..392156 + 1227 WP_001105482.1 RNA-splicing ligase RtcB -
IMQ59_RS01735 392160..393188 + 1029 WP_021574798.1 RNA 3'-terminal phosphate cyclase -
IMQ59_RS01740 393238..393723 - 486 WP_001626109.1 GNAT family N-acetyltransferase Toxin
IMQ59_RS01745 393714..393992 - 279 WP_000801912.1 DUF1778 domain-containing protein Antitoxin
IMQ59_RS01750 394059..396764 - 2706 WP_000906970.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-92)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17666.61 Da        Isoelectric Point: 9.4066

>T176633 WP_001626109.1 NZ_CP062811:c393723-393238 [Escherichia coli]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYLITL
E

Download         Length: 486 bp

>T176633 NZ_CP082854:8524-8835 [Legionella anisa]
ATGCATGTTATCTCTAAAAAACCATTTGTTGAGGCTGCTAAGAAATATCCGAATCAACGTCAGGCGATTTTAGATTTATA
TCGTGTGCTAGACAAGATAACAGTGAATACCCCATTGGAAATGAAAGCAATTTTTCCAAGCCTTGATAACTTTAAGTATA
AAGATAAGTGGTGGATTATTGATATAGGAGGTAATCATTTACGACTGATGGCTTTTATTCAATTTTCACAAAATAGAATC
TATGTGAAACATATTGTCACTCATGCTGAATACGATAGATTATGTGAGCAGTACAGGAGGAATAAACAATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10420.94 Da        Isoelectric Point: 4.6336

>AT176633 WP_000801912.1 NZ_CP062811:c393992-393714 [Escherichia coli]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE

Download         Length: 279 bp

>AT176633 NZ_CP082854:8832-9263 [Legionella anisa]
ATGATTTCTGAACAGGTTATTTTAAACAAATTTATTGATTTCACTAAAGTTGCAGCTCCTGTTCTTTCTTTAAAAGATGA
ACAGGCTTATGAAGATGCTTTGACGATGATGGAGCATTTAATGGAATCTGTTGGTGAGCAACGTAATAAACCCGAAAATA
TATTAATTGGATTGTTGGCGCACGCAATAGAAGAATATGAGTCTAAAGATGAAGAAATTTCTGATTTTGTGAGTCAGTCT
ATGTCAGATCGGGGCGATGTTGCCCTACTCAGAATGATTATCGATCAGCACCAATTAACACTCAGTGATTTACCTGAGGT
AGGGCATAAGTCTCTCATATCAAAAATATTATCTGGGGAGCGAAATCTTACTCGATCACACATCGAAAAATTAAGTAAAC
GGTTTCATATTGACCCTGGGTTGTTTTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y2XJ17

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LHB9

References