Detailed information of TA system TA176632

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 303643..304286
• Replicon: chromosome
• Accession: NZ_CP062811
• Organism: Escherichia coli strain Res13-Sevr-PER07-33

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: IMQ59_RS01295
• Protein ID: WP_042099886.1
• Coordinates: 303643..303930 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q31VE4
• Locus tag: IMQ59_RS01300
• Protein ID: WP_000593554.1
• Coordinates: 303927..304286 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMQ59_RS01280	298660..299727	+	1068	WP_000361491.1	HlyD family efflux transporter periplasmic adaptor subunit	-
IMQ59_RS01285	299724..302459	+	2736	WP_001626155.1	ribosome-associated ATPase/putative transporter RbbA	-
IMQ59_RS01290	302459..303583	+	1125	WP_001314210.1	ABC transporter permease	-
IMQ59_RS01295	303643..303930	+	288	WP_042099886.1	type II toxin-antitoxin system HicA family toxin	Toxin
IMQ59_RS01300	303927..304286	+	360	WP_000593554.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IMQ59_RS01305	304336..305196	-	861	WP_001626154.1	class II aldolase	-
IMQ59_RS01310	305228..305497	-	270	WP_001626153.1	HPr family phosphocarrier protein	-
IMQ59_RS01315	305487..306995	-	1509	WP_001626152.1	xylulose kinase	-
IMQ59_RS01320	306988..308346	-	1359	WP_001308116.1	PTS galactitol transporter subunit IIC	-
IMQ59_RS01325	308423..308704	-	282	WP_000084025.1	PTS sugar transporter subunit IIB	-
IMQ59_RS01330	308701..309174	-	474	WP_001161650.1	PTS sugar transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (34-84)

Antitoxin

• Uncharacterised protein family HicB (60-112)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10462.93 Da
• Isoelectric Point: 7.7845

>T176632 WP_042099886.1 NZ_CP062811:303643-303930 [Escherichia coli]
IRTCHENPGTGFTEETKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSAACFHRPHPSPDTDKGA
VESVRDWLLSIGVKP

Nucleotide

• Length: 288 bp

>T176632 NZ_CP082854:3128-3490 [Legionella anisa]
ATGAAAAGAATGATAACAATAATCGAATTTCCTGGGTTTCTTTCTCAAGTTGGAAACTCAATTAGCGCGGCCGAACGCGA
TGAATTTATTAATTTTATCGCCAGAAATCCAGAGGTTGGGGATCTAATCCCTGGAACTGGTGGAGTGAGAAAAGTGCGTT
GGGGAAGTAAGAATAAGGGAAAAAGCGGTGGCGTCAGGGTAATTTATTATTTTTACGATGAGCTTGCCCCTGTTTTTTTG
TTAACTGCTTATGGAAAAGGTGAAAAAGAGAATTTAACTGCCGAGCAAAAGAAACAAATATCAGCTCTTGCTCAAGTTTT
AAAGTCTGAGTGCAAGAACCGTAGGAGTCAAGAACATGACTAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13359.25 Da
• Isoelectric Point: 4.8838

>AT176632 WP_000593554.1 NZ_CP062811:303927-304286 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Nucleotide

• Length: 360 bp

>AT176632 NZ_CP082854:3483-3788 [Legionella anisa]
ATGACTAATCGAAATATAGGAAATGAAATAATTCAAGGCATGGAAGAGGCTATTGAATATATTCGAGGGAATAAAGGATC
TGCAAAGGTTCATAAAGTTGAAATACCCAATGAAATTGATGTTCGGGAAATTCGAGAGAATCTTAATTTATCCCGAAAAG
AATTCGCAGACAGTTTTGGCTTTAGTCCGAGAACGTTGCAGCATTGGGAGCAGGGGGATAGAGCCCCGCATGGCGCAGCT
AAAGTCCTGTTGTTGCTTTTGCAGCGAGAGCCAGCAACTATTGCTAAAATTTTACGCCAAAATTGA

Structures

Antitoxin

• AlphaFold DB: A0A6H2GM94