Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 26238..26769 Replicon plasmid pRK1-5
Accession NZ_CP062809
Organism Cupriavidus basilensis strain DSM 11853

Toxin (Protein)


Gene name relE Uniprot ID I2ALI9
Locus tag F7R26_RS40485 Protein ID WP_011114071.1
Coordinates 26488..26769 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID I2ALI8
Locus tag F7R26_RS40480 Protein ID WP_011114070.1
Coordinates 26238..26501 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7R26_RS40435 21348..22112 - 765 WP_013397098.1 ParA family protein -
F7R26_RS40440 22109..22417 - 309 WP_011255197.1 transcriptional regulator -
F7R26_RS40445 22661..22948 - 288 Protein_20 DUF2761 domain-containing protein -
F7R26_RS40450 22950..23276 - 327 WP_012478184.1 hypothetical protein -
F7R26_RS40455 23486..23722 - 237 WP_011255200.1 stable inheritance protein KleA -
F7R26_RS40460 23880..24137 - 258 WP_012478185.1 hypothetical protein -
F7R26_RS40465 24154..25362 - 1209 WP_012478186.1 hypothetical protein -
F7R26_RS40470 25374..25637 - 264 WP_011296181.1 hypothetical protein -
F7R26_RS40475 25637..26065 - 429 WP_011114069.1 antirestriction protein -
F7R26_RS40480 26238..26501 + 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
F7R26_RS40485 26488..26769 + 282 WP_011114071.1 type II toxin-antitoxin system YafQ family toxin Toxin
F7R26_RS40490 28155..29378 - 1224 WP_011013257.1 replication initiator protein A -
F7R26_RS40495 29427..29765 - 339 WP_011013259.1 single-stranded DNA-binding protein -
F7R26_RS40500 29875..30234 + 360 WP_011013260.1 transcriptional regulator -
F7R26_RS40505 30549..31514 + 966 WP_011013261.1 P-type conjugative transfer ATPase TrbB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..81787 81787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10743.19 Da        Isoelectric Point: 7.4750

>T176631 WP_011114071.1 NZ_CP062809:26488-26769 [Cupriavidus basilensis]
MRQIERTGQFKRDYKREAKGQHRATLDADLVPVLVALADDQPLEPRHRDHALTGDWKDHRDCHVKPDLVLIYQKPDADTL
RLVRLGSHSELGL

Download         Length: 282 bp

>T176631 NZ_CP082854:1029-1226 [Legionella anisa]
ATGAAAAGCGCAGAAATAATAAAAATAATAGAACGCGATGGTTGGGTGCAATGTCACCAGAAGGGGAGTCATTGTCAATT
TAAACATCCCGCCAAAAAGGGCAGGGTGACAGTGCCTCATCCTAAAAAAGATTTACCTATTAAAACGGTGGTCAGTATCT
TTAAGCAGGCTGGTATAAATAAGGAGGATATAAAATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9255.82 Da        Isoelectric Point: 5.7905

>AT176631 WP_011114070.1 NZ_CP062809:26238-26501 [Cupriavidus basilensis]
MAANQLVQTRIDGAIKEEAAAVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIEAMKEARKGKLPRFATVNDLM
ADLHAAD

Download         Length: 264 bp

>AT176631 NZ_CP082854:1223-1627 [Legionella anisa]
ATGAGATATCCTGTAGTGATCCATAAAGATGAACAGAGTGATTTTGGTGTGAGTATCCCCGATATTCCTGGGTGCTATTC
TGCTGGTAGCACTTATGATGAAGCATTAACCAATGCTATTGAGGCGATTGAATGCCATCTCGAAGGGTTGTTAATGGATA
ATGAGTCCCTTCCGGTAGGTACAACAATTGATCGATGGATTAATGATGAAGAGTTTCAGGGTGGCGTATGGGCATTTATT
GACATTGATTTAAGCCAAATATCAGGTAAGGCAAAACGCATTAATATCACTATGCCAGAGCGGGTTTTAAGCCTGATTGA
TTTGTATGCTAAAAATCATTCTATAAAAAATCGCTCTTCTTTTTTAGCAGATGCAGCACTTAGCTATATGGAAAGTCATA
AATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9V4I5

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9V3I2

References