Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 99177..99742 Replicon plasmid pRK1-2
Accession NZ_CP062806
Organism Cupriavidus basilensis strain DSM 11853

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F7R26_RS38050 Protein ID WP_150992786.1
Coordinates 99177..99548 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag F7R26_RS38055 Protein ID WP_150992784.1
Coordinates 99545..99742 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7R26_RS38010 94899..95402 - 504 WP_150992799.1 hypothetical protein -
F7R26_RS38015 95917..96147 + 231 WP_150992797.1 hypothetical protein -
F7R26_RS38020 96342..96587 - 246 WP_150992835.1 hypothetical protein -
F7R26_RS38025 97202..97828 - 627 WP_045242046.1 hypothetical protein -
F7R26_RS38030 97845..98036 - 192 WP_150992792.1 hypothetical protein -
F7R26_RS38035 98044..98616 - 573 WP_150992790.1 DUF4337 domain-containing protein -
F7R26_RS38040 98629..98805 - 177 WP_170302018.1 hypothetical protein -
F7R26_RS38045 98849..99091 - 243 WP_150992788.1 hypothetical protein -
F7R26_RS38050 99177..99548 - 372 WP_150992786.1 PIN domain-containing protein Toxin
F7R26_RS38055 99545..99742 - 198 WP_150992784.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
F7R26_RS38060 100173..100622 + 450 WP_170302017.1 hypothetical protein -
F7R26_RS38065 100526..100938 + 413 Protein_102 hypothetical protein -
F7R26_RS38070 100987..102023 + 1037 Protein_103 DNA-binding protein -
F7R26_RS38075 102369..103523 + 1155 WP_150992782.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..355033 355033


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13630.84 Da        Isoelectric Point: 4.8728

>T176630 WP_150992786.1 NZ_CP062806:c99548-99177 [Cupriavidus basilensis]
MILVDTSVWIDHINASDPMLISLLAEERVLAHPYVIGEISLGSLRDRDVVLGALLDLPRALVATPEETFYLIEREGLFNR
GIGYVDTSLLASARLQPGITIWTRDKRLKKIADELNLGAVLAH

Download         Length: 372 bp

>T176630 NZ_CP082853:63058-63348 [Legionella anisa]
ATGGTTAATGTATTAAAACTTTGTTCAAGTACCCAGTTTAAAAAAGACTTAAAAAGAGTAGCGAAGCAAGGAAAAAATCG
AAAGTTAATTGATGATGTTATTGAAAAACTGCAGCGCCAAGAACCACTACCTCAAAAAAATCGTGATCATGCTTTGGTAG
GAGATTATAAAGGCTATAGAGAATGCCACATAACGCCTGATTGGTTATTAATTTATCGTATAACAAATAATAATGCTGTG
GAATTGTTGGAGTTAACAAGAACAGGATCGCATTCCGAATTATTTAGGTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7072.21 Da        Isoelectric Point: 10.6647

>AT176630 WP_150992784.1 NZ_CP062806:c99742-99545 [Cupriavidus basilensis]
MRTTIALDDDLIAKAQAYTGLEEKTALVREALKALIQREAAKRLANLGGSQPGIKGAPRRRQVVE

Download         Length: 198 bp

>AT176630 NZ_CP082853:62805-63065 [Legionella anisa]
ATGGGTAGAGCAGCATCAATCCACGCTAGAATTGATCCAACATTAAAGCATGATGCCGAAAAAATATTGCATCAATTAGG
ATTAAATACATCTCAGGCAATTAATGCATTCTATGCGCAAATCGTTCATGTTAGAGGAATACCTTTTGAACTTAAGTTAC
CTAATGAAGAAACTATAGCAGCGATGAAAGAGCTCGATTCAGGCAAGGTAAAAACCTATGATTCTATGAAAGATTTGTGG
AATGAAATAGACAATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References