Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1963987..1964521 Replicon chromosome
Accession NZ_CP062804
Organism Cupriavidus basilensis strain DSM 11853

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag F7R26_RS29610 Protein ID WP_150989398.1
Coordinates 1963987..1964277 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag F7R26_RS29615 Protein ID WP_150989401.1
Coordinates 1964267..1964521 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7R26_RS29580 1959194..1959691 - 498 WP_150989383.1 GNAT family N-acetyltransferase -
F7R26_RS29585 1959735..1960271 - 537 WP_150989386.1 HD domain-containing protein -
F7R26_RS29590 1960361..1961176 - 816 WP_193692178.1 phosphonate ABC transporter, permease protein PhnE -
F7R26_RS29595 1961255..1962247 - 993 WP_150989389.1 phosphonate ABC transporter substrate-binding protein -
F7R26_RS29600 1962317..1963156 - 840 WP_150989392.1 phosphonate ABC transporter ATP-binding protein -
F7R26_RS29605 1963557..1963964 + 408 WP_150989395.1 hypothetical protein -
F7R26_RS29610 1963987..1964277 - 291 WP_150989398.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F7R26_RS29615 1964267..1964521 - 255 WP_150989401.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
F7R26_RS29620 1964718..1965368 - 651 WP_150989404.1 VTT domain-containing protein -
F7R26_RS29625 1965570..1965971 + 402 WP_150989407.1 OsmC family protein -
F7R26_RS29630 1966036..1967268 - 1233 WP_150989411.1 alpha/beta fold hydrolase -
F7R26_RS29635 1967592..1967996 + 405 WP_150989414.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
F7R26_RS29640 1968076..1968450 - 375 WP_150989417.1 RNA chaperone Hfq -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11253.03 Da        Isoelectric Point: 10.5340

>T176628 WP_150989398.1 NZ_CP062804:c1964277-1963987 [Cupriavidus basilensis]
ISYELAFHEDALKEWKKLDASIKDQFRKQLEKRLAEPRVPSAKLSGKDMKDVYKIKLRDAGYRLVYEVNDRTVTVLVLAV
GRRDKSEAYRRAGVRR

Download         Length: 291 bp

>T176628 NZ_CP082849:c52090-51893 [Legionella pneumophila]
ATGAAAAGCGCAGAAATAATAAAAATAATTGAACGCGATGGTTGGGTGCAATGCCATCAGAAAGGAAGTCATTGCCAATT
TAAACATCCCACCAAAAAGGGTAGGGTGACAGTACCTCATCCTAAAAAAGATTTACCTATAAAAACAGTGGCCAGTATCT
TTAAACAAGCTGGTATTAATAAGGAGGATATAAAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9215.60 Da        Isoelectric Point: 7.0117

>AT176628 WP_150989401.1 NZ_CP062804:c1964521-1964267 [Cupriavidus basilensis]
MTVTRAIYATATVSITDLRRNPGAIIEEAGNEPVAVLNHNRPAAYLVPAQAFEALMDRLEDIELAEIVRQRRGGKSVKVS
LDKL

Download         Length: 255 bp

>AT176628 NZ_CP082849:c51896-51492 [Legionella pneumophila]
ATGAGATATCCTGTAGTAATACATAAAGACGAACATAGTGATTTTGGTGTAATTGTCCCTGATATTCCTGGATGCTATTC
TTCTGGTAGCACTTATGATGAACCTTTAACTAACGTAATTGAGGCAATTGAATGCCATTTGGAAGGATTATTAATAGATA
ATGAGCCTCTTCCAGTTGGTACAACAATTGACCGATGGATTAATGATGAAGAGTTTCAGGGCGGGGTATGGGCATTTGTT
GACATTGATTTAAGCCAAATATCGGGTAAAGCAAAACGCATTAATATCACTATGCCAGAGCGCATTTTAAGTCTCATCGA
TCTGTATGCCAAAAACCATGCGATAAAAAATCGTTCCTCCTTTTTGGCCGATGCAGCTCTGAGTTATATGGAAAGTCATA
AGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References