Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 493002..493633 Replicon chromosome
Accession NZ_CP062804
Organism Cupriavidus basilensis strain DSM 11853

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F7R26_RS23175 Protein ID WP_150984262.1
Coordinates 493002..493394 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag F7R26_RS23180 Protein ID WP_150984261.1
Coordinates 493391..493633 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7R26_RS23150 488096..488650 + 555 WP_150984452.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
F7R26_RS23155 488892..489289 + 398 Protein_435 FAD-dependent oxidoreductase -
F7R26_RS23160 489378..490172 - 795 WP_150984266.1 SDR family oxidoreductase -
F7R26_RS23165 490498..491535 - 1038 WP_170301750.1 OmpA family protein -
F7R26_RS23170 491752..492957 + 1206 WP_150984263.1 formate-dependent phosphoribosylglycinamide formyltransferase -
F7R26_RS23175 493002..493394 - 393 WP_150984262.1 type II toxin-antitoxin system VapC family toxin Toxin
F7R26_RS23180 493391..493633 - 243 WP_150984261.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
F7R26_RS23185 493792..494490 + 699 WP_150984260.1 amino acid racemase -
F7R26_RS23190 494558..494941 + 384 WP_150984259.1 DUF427 domain-containing protein -
F7R26_RS23195 494966..495769 - 804 WP_150984258.1 GntR family transcriptional regulator -
F7R26_RS23200 495968..496864 + 897 WP_150984257.1 isocitrate lyase/PEP mutase family protein -
F7R26_RS23205 496867..498267 + 1401 WP_150984256.1 3-isopropylmalate dehydratase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin

SpoVT-AbrB domain

(7-42)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14443.37 Da        Isoelectric Point: 6.9908

>T176626 WP_150984262.1 NZ_CP062804:c493394-493002 [Cupriavidus basilensis]
VKFLLDSNAVIALLRGHAGFLNRLRQHQPQDFGIPAIVAHELFYGAFKSQRATENLARVEGLQFEVLDFDREDARHAGEL
RAALATAGTPIGPYDVLIAGQARARALTLVTHNTREFQRVPGLRVEDWEG

Download         Length: 393 bp

>T176626 NZ_CP082848:c544734-543430 [Legionella pneumophila]
ATGGTAATGCGTAAATTATACATATTGATGAACAATGAGCTCGTGGGGGAGCTTACCCAGGATAATGCAGGTGGTTTGAG
TTTTTCCTACGTTGCTGACTGGATTTCCAAACCGCATTCACGCCCAGTTTCTTTATCGTTACCGTTAGTAAATCAAAAAT
TTTCAGGAGAAGTTGTTTATAACTTTTTTGATAATTTACTTCCCGATAATCCACAGATAAGAGCCAGAATTCAAGCTCGT
TTTCAGGCAAAATCATCGCGACCGTTTGATTTATTGGCGTTAATTGGCAGTGATTGTGTTGGTGCAATACAAATTGTTGA
ACGTATTCCTCAGACACAGCGTCTAAGCATTGAAAGTCACGTTGTCAGTGAGGCCGAGATAGCTCGTACTTTACGTTCTT
ACCAAACCTCACCACTGGGAATGGATAAAGAGGATGATGAGTTTAGAATCTCAATAGCCGGTGCTCAGGAAAAAACGGCT
TTTCTATATTACCAAAATGAATGGCATAAACCATTTGGACCTACACCAACAACTCACATATTCAAATTACCTATTGGATA
TTTACCACATCAAGGAATTGATTTAAGTGAGAGTTGTGAAAATGAGCATCTCTGTTTACTACTAGCCAGCAAATTTGGTT
TAGATGTTGCAAAATCAAAAATCTTACAATTCGAAGATGAAAAAGTGCTGGTTGTCGAAAGATTTGATAGAAAATGGAGT
CGAGATAACCGTTATATACTCAGGTTACCGCAAGAAGACCTATGCCAAGCGTTGGGTTATTCACCAAATTTAAAATATCA
GTCAGATGGTGGCCCCGGTATTAAAGAAATTATGCAGCTACTTAATGGCTCACAGCAGCCTCAAAAAGACAGAGATGAAT
TTTTCAGAGCACAAGTTGTTTACTGGTGCCTTGGTGCTATTGATGCGCATGCCAAAAATTTCAGTATAAGTATACAACCA
CAAGGCGGTTACCAGCTCACCCCCTTATACGACATCATTTCAGCCTATCCTATCGTGGAACAAAAACAGCTATCCTTTAA
GAAATTGAAAATGGCAATGGCTTTATATGGTAAAAATATTCATTACAAGATTGACGGTATTCAAAAAAGACACTTTATTG
AAACAGCAAAATACGTTAAATATTCTAAAATTAAAGCAGCTCAGATTTTTGAACAAGTGATTGACCGTATTGATTCTGCT
ATCGATGAGGTCTCAAGACAATTACCAAACCACTTCCCAGAAAAGATTGCAGATCCAATCTTCAAAGGGATGAGAGCTTT
TAAGGAGCGAATGATATCCACATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9144.25 Da        Isoelectric Point: 4.5720

>AT176626 WP_150984261.1 NZ_CP062804:c493633-493391 [Cupriavidus basilensis]
MDTAKIFWSGRSQAVRLPKDFRFEASEVRIRRHGNAVILEPIASDWAWLDPIVGPLDEDFAQAASEQPADQSRPELDFFK

Download         Length: 243 bp

>AT176626 NZ_CP082848:c544967-544728 [Legionella pneumophila]
ATGATCATTAGCTCAGCAAAAGATTTAGCATTATATTTAAATGACAAGCGCAAACAACTCAAAATGAGTCAATCTGAAGT
TGCCGATTTAGTCGGCTTAAAACAGGATACCATATCAAAGTTTGAAAATAGCCCCGATAATAGTCGAATTGATACCTTAT
TTAGAATATTGTCCGCCCTAAATTTAAATATGAGCCTTGTTGAAAAAGATCAAAAAACTCATGAAGAGATAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References