Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 270280..270919 Replicon chromosome
Accession NZ_CP062804
Organism Cupriavidus basilensis strain DSM 11853

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F7R26_RS22160 Protein ID WP_150984429.1
Coordinates 270503..270919 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag F7R26_RS22155 Protein ID WP_150984430.1
Coordinates 270280..270516 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7R26_RS22130 265841..266737 - 897 WP_150984434.1 LysR family transcriptional regulator -
F7R26_RS22135 266854..267975 + 1122 WP_043352961.1 muconate/chloromuconate family cycloisomerase -
F7R26_RS22140 268013..268291 + 279 WP_150984433.1 muconolactone Delta-isomerase -
F7R26_RS22145 268389..269375 + 987 WP_150984432.1 tripartite tricarboxylate transporter substrate binding protein -
F7R26_RS22150 269383..270171 + 789 WP_150984431.1 3-oxoadipate enol-lactonase -
F7R26_RS22155 270280..270516 + 237 WP_150984430.1 DNA-binding protein Antitoxin
F7R26_RS22160 270503..270919 + 417 WP_150984429.1 type II toxin-antitoxin system VapC family toxin Toxin
F7R26_RS22165 270965..271801 - 837 WP_150984428.1 DUF3047 domain-containing protein -
F7R26_RS22170 272006..272125 - 120 Protein_240 3-ketoacyl-ACP reductase -
F7R26_RS22175 272116..272244 + 129 Protein_241 LysR family transcriptional regulator -
F7R26_RS22180 272338..272520 - 183 WP_150984427.1 hypothetical protein -
F7R26_RS22185 272582..275677 - 3096 WP_150984426.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15382.61 Da        Isoelectric Point: 6.7617

>T176625 WP_150984429.1 NZ_CP062804:270503-270919 [Cupriavidus basilensis]
MYLIDTNVISEMRKRERADKGVRAFFRQAAKQESELYLSVVTVGELRRGVELIQHRGDHAQGALLATWLDTVLQEFGAHI
LAVDAEIGQLWGRLRVPHAEHALDKLIAATALIHDLTVVTRNVSDFAGTGARVLNPFE

Download         Length: 417 bp

>T176625 NZ_CP082848:c371122-370847 [Legionella pneumophila]
GTGAAGGAATTATTATCTGATGAGGAGTATGCTGAGTTTCAAGAGTATCTTGCTGATAATCCTTTAGCTGGAGACGTAAT
TCAGCAAACCGGCGGACTGCGAAAAGTTCGATGGTCATTTCAAGGCAAAGGGAAGCGAGGTGGTGTTAGAATTATTTATT
ATTATGTCACTCCTGCTTCACAAATAAGACTCTTACTTATTTATAAAAAAGGTATTCAAGATGATCTGACTACAGATCAA
AAGAAAATGTTACGGCAATTAAATGAACGGTGGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8593.58 Da        Isoelectric Point: 5.5511

>AT176625 WP_150984430.1 NZ_CP062804:270280-270516 [Cupriavidus basilensis]
MANLLVRGIDEALVQRLREQAAAHGRSAEAEHREILARALHTTRRKSFAEVLASMPDVGEDSDFERVDQPGGAAHVFD

Download         Length: 237 bp

>AT176625 NZ_CP082848:c370844-370554 [Legionella pneumophila]
ATGGATAAAAAATTATTTGAACGATTATACGAAAGTATGACTCAGATGAACGAAATTATTGATGGTGAGCGTGTTCCTTC
ACGTGAGTTCGTAGTGGATGCTGTTCATGTAAAAGAAATTAGAAAAAAAACAGGCCTAACCCAAGAAAAATTTTGTCATT
TAATTGATGTAAATATTGGAACATTAAGAAATTGGGAGCAGGGGAGAAGAGAGCCAACAGGTCCTGCAAAAGCTCTTCTT
CGCGCAATAAATAAAGATCCTGAACATGTATTAGCAGCATTAGCTGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References