Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4723231..4723747 Replicon chromosome
Accession NZ_CP062792
Organism Klebsiella pneumoniae strain 33Kpn12

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag IFY65_RS23360 Protein ID WP_004178374.1
Coordinates 4723231..4723515 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IFY65_RS23365 Protein ID WP_002886901.1
Coordinates 4723505..4723747 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFY65_RS23335 4718707..4719015 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
IFY65_RS23340 4719100..4719273 + 174 Protein_4574 hypothetical protein -
IFY65_RS23345 4719276..4720019 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IFY65_RS23350 4720376..4722514 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
IFY65_RS23355 4722763..4723227 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IFY65_RS23360 4723231..4723515 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IFY65_RS23365 4723505..4723747 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IFY65_RS23370 4723825..4725735 - 1911 WP_032420841.1 BglG family transcription antiterminator -
IFY65_RS23375 4725758..4726912 - 1155 WP_004178372.1 lactonase family protein -
IFY65_RS23380 4726979..4727719 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T176620 WP_004178374.1 NZ_CP062792:c4723515-4723231 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T176620 NZ_CP082846:c2217073-2216630 [Mycolicibacterium smegmatis]
ATGGCCAAACTTTCCGTCTCTGTCGAAGTTCCTTTGCCGCCGGAGCAGGCGTGGGAGTATGCCTCCGATCTGTCCCGGTA
CCACGAGTGGCTCAGCATTCACCGGGCCTGGCGCTCGAAGTTGCCCGAGACCCTGGAGAAGGGCACGGTGATCGAGTCGA
TCGTCGAGGTCAAGGGCATGCTCAACCGGGTCAGGTGGACGCTGGTCCACTACAAGCCCCCGCAGGCGCTCACACTCAAC
GGTGACGGCCGCGGTGGGGTCAAGGTCAAGCTGATCGGCAAGATCAAGCCCACCGACAACGGCGCGACGGTGGGCTTCGA
CCTGCACCTCGGCGGCCCGGCCCTGTTCGGGCCCATCGGCATGGTGGTGGCCGCGGCGCTCAAGAGCGACATCCAGGAGT
CGCTCAACCGCTTCAAGCAGCTCTACGCCCCGTCCGCGACCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT176620 WP_002886901.1 NZ_CP062792:c4723747-4723505 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT176620 NZ_CP082846:c2217271-2217083 [Mycolicibacterium smegmatis]
ATGGGATTCCTGGACAAGGCCAAAGACCTCTTGTCGCAGAACGCCGACAAGGTGGACACCGTCATTGACAAGGCCGGCGA
CATGATCGACGAGAAGACGCAGGGCAAGTACGCCCAGCACGTCGACAAGGCGCAGGACGCCGCGAAGAACGCCATCCGCA
AAGACGACCCTCAAGAACCACAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References