Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2617797..2619385 Replicon chromosome
Accession NZ_CP062792
Organism Klebsiella pneumoniae strain 33Kpn12

Toxin (Protein)


Gene name hipA Uniprot ID A0A8E1ZGL5
Locus tag IFY65_RS13095 Protein ID WP_048270684.1
Coordinates 2617797..2619119 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IFY65_RS13100 Protein ID WP_004176198.1
Coordinates 2619119..2619385 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFY65_RS13080 2612853..2615354 + 2502 WP_032420041.1 fimbrial biogenesis outer membrane usher protein -
IFY65_RS13085 2615342..2616346 + 1005 WP_032420040.1 type 1 fimbrial protein -
IFY65_RS13090 2616488..2617780 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
IFY65_RS13095 2617797..2619119 - 1323 WP_048270684.1 type II toxin-antitoxin system HipA family toxin Toxin
IFY65_RS13100 2619119..2619385 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
IFY65_RS13105 2619650..2619976 - 327 WP_004143476.1 hydroxyisourate hydrolase -
IFY65_RS13110 2619973..2620473 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
IFY65_RS13115 2620451..2621830 - 1380 WP_004184021.1 purine permease -
IFY65_RS13120 2622176..2623330 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
IFY65_RS13125 2623311..2624234 - 924 WP_192906380.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5358

>T176616 WP_048270684.1 NZ_CP062792:c2619119-2617797 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T176616 NZ_CP082844:2322663-2322920 [Nocardia asteroides]
ATGAAGGTCGTTTTCTCCGAGTCCGCTTGGGAGGAATATTCGGCGTGGCTGCAGCGCGACCGGCTTGTTTTGAAGAAGGT
CAATGTGCTGATCAAAGCCATTCTGAGCGACCCCTTCGAAGGCATCGGTAAGCCCGAGCCGTTGAAGCACGACCTGTCGG
GCTATTGGTCACGCCGGATCACGCAGGAGCATCGCATCGTCTACCGGGTCGTCGACGATGCGATATGGATTGCCAAGGTC
GGCAAGCACTACGACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT176616 WP_004176198.1 NZ_CP062792:c2619385-2619119 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT176616 NZ_CP082844:2322418-2322666 [Nocardia asteroides]
ATGGCTGCCGCGATTACCGCTAGTGAGGCGCGCAAGAATCTATTCCCCTTGATCAGGAAGGTCAACGAGGATCACGACAC
AATCGAGATCGTGTCCAAGGGGGGGAACGCCGTGTTGATATCCAAGGAAGACTACGACTCGCTGATGACGACCGTGGAGT
TGTTGAGCGGGCGTGACGGGGCGCGGCTACGCCGATCGATTCAGGAACTCGAGGGTGGTGGCGGCGTCGTACGCGACCTC
ATCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References