Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 838551..839208 Replicon chromosome
Accession NZ_CP062792
Organism Klebsiella pneumoniae strain 33Kpn12

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IFY65_RS04205 Protein ID WP_002916310.1
Coordinates 838798..839208 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IFY65_RS04200 Protein ID WP_002916312.1
Coordinates 838551..838817 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFY65_RS04175 833707..835140 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
IFY65_RS04180 835259..835987 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
IFY65_RS04185 836037..836348 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
IFY65_RS04190 836512..837171 + 660 WP_002916317.1 hemolysin III family protein -
IFY65_RS04195 837322..838305 - 984 WP_192906254.1 tRNA-modifying protein YgfZ -
IFY65_RS04200 838551..838817 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IFY65_RS04205 838798..839208 + 411 WP_002916310.1 protein YgfX Toxin
IFY65_RS04210 839215..839736 - 522 WP_004144730.1 flavodoxin FldB -
IFY65_RS04215 839837..840733 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IFY65_RS04220 840756..841469 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IFY65_RS04225 841475..843208 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T176607 WP_002916310.1 NZ_CP062792:838798-839208 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T176607 NZ_CP082840:c5364745-5364362 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT176607 WP_002916312.1 NZ_CP062792:838551-838817 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT176607 NZ_CP082840:c5364987-5364745 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References