Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 4587908..4588544 Replicon chromosome
Accession NZ_CP062790
Organism Cytobacillus oceanisediminis strain YPW-V2

Toxin (Protein)


Gene name mazF Uniprot ID W7KPR3
Locus tag IIE26_RS22895 Protein ID WP_009336311.1
Coordinates 4588194..4588544 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A160MHA2
Locus tag IIE26_RS22890 Protein ID WP_026041666.1
Coordinates 4587908..4588189 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IIE26_RS22870 4583804..4584529 - 726 WP_192908030.1 rhomboid family intramembrane serine protease -
IIE26_RS22875 4584694..4585047 + 354 WP_009336315.1 holo-ACP synthase -
IIE26_RS22880 4585192..4586205 + 1014 WP_019381248.1 outer membrane lipoprotein carrier protein LolA -
IIE26_RS22885 4586260..4587531 + 1272 WP_009336313.1 alanine racemase -
IIE26_RS22890 4587908..4588189 + 282 WP_026041666.1 CopG family ribbon-helix-helix protein Antitoxin
IIE26_RS22895 4588194..4588544 + 351 WP_009336311.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
IIE26_RS22900 4588926..4589759 + 834 WP_009336310.1 STAS domain-containing protein -
IIE26_RS22905 4589756..4590118 + 363 WP_009336309.1 STAS domain-containing protein -
IIE26_RS22910 4590123..4590524 + 402 WP_009336308.1 anti-sigma regulatory factor -
IIE26_RS22915 4590536..4591546 + 1011 WP_019381250.1 PP2C family protein-serine/threonine phosphatase -
IIE26_RS22920 4591607..4591939 + 333 WP_009336305.1 anti-sigma factor antagonist -
IIE26_RS22925 4591936..4592409 + 474 WP_009336304.1 anti-sigma B factor RsbW -
IIE26_RS22930 4592387..4593181 + 795 WP_009336303.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 4.8998

>T176604 WP_009336311.1 NZ_CP062790:4588194-4588544 [Cytobacillus oceanisediminis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEAVQISLGLIEF

Download         Length: 351 bp

>T176604 NZ_CP082840:c4797999-4797466 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10817.30 Da        Isoelectric Point: 7.2025

>AT176604 WP_026041666.1 NZ_CP062790:4587908-4588189 [Cytobacillus oceanisediminis]
VSDSSTTTEIMVKLPQHLLTELDGFAKQENVNRSEFIYQATKMYLRERKKRQIRESMRRGYMEMAKINLTIASEAFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp

>AT176604 NZ_CP082840:c4798276-4798010 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A169FD46

Antitoxin

Source ID Structure
AlphaFold DB A0A160MHA2

References