Detailed information of TA system TA176603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3443056..3443660
• Replicon: chromosome
• Accession: NZ_CP062789
• Organism: Janibacter indicus strain TT2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A7G7HSU6
• Locus tag: IGS73_RS16925
• Protein ID: WP_072625875.1
• Coordinates: 3443056..3443436 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IGS73_RS16930
• Protein ID: WP_084449641.1
• Coordinates: 3443433..3443660 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IGS73_RS16895	3438873..3439814	+	942	WP_072625869.1	LysR family transcriptional regulator	-
IGS73_RS16900	3439811..3440401	-	591	WP_072625870.1	DUF998 domain-containing protein	-
IGS73_RS16905	3440398..3440724	-	327	WP_159451129.1	hypothetical protein	-
IGS73_RS16910	3440721..3441650	-	930	WP_072625872.1	alpha/beta hydrolase	-
IGS73_RS16915	3441743..3442378	+	636	WP_072625873.1	DUF3105 domain-containing protein	-
IGS73_RS16920	3442375..3443004	+	630	WP_084449642.1	DUF305 domain-containing protein	-
IGS73_RS16925	3443056..3443436	-	381	WP_072625875.1	type II toxin-antitoxin system VapC family toxin	Toxin
IGS73_RS16930	3443433..3443660	-	228	WP_084449641.1	antitoxin	Antitoxin
IGS73_RS16935	3443714..3444688	+	975	WP_192911095.1	threonine/serine dehydratase	-
IGS73_RS16940	3444909..3448298	+	3390	WP_192911096.1	exodeoxyribonuclease V subunit gamma	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (3-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13446.48 Da
• Isoelectric Point: 4.8616

>T176603 WP_072625875.1 NZ_CP062789:c3443436-3443056 [Janibacter indicus]
VIVVDASAMVEALVGRAPDPRLLDALAGVVEAPQHLDVEVLSVLRGLTLGAKLPAARAEEALGAYLDLDITRRDVAPFAR
RVWSLRHQYTSYDAAYLALAEGLDAPLYTCDRKLAAGGHTAEVVVI

Nucleotide

• Length: 381 bp

>T176603 NZ_CP082840:4185258-4185476 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8288.35 Da
• Isoelectric Point: 5.0644

>AT176603 WP_084449641.1 NZ_CP062789:c3443660-3443433 [Janibacter indicus]
MPTLYIRDVPDDVAETLKQRAAADGQSLSAYVAGALLRLAERPTNAEVVERLRQVDRTLAPASEEIVSTLHESRR

Nucleotide

• Length: 228 bp

>AT176603 NZ_CP082840:4184857-4185231 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: A0A7G7HSU6