Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1816114..1816718 Replicon chromosome
Accession NZ_CP062789
Organism Janibacter indicus strain TT2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IGS73_RS08735 Protein ID WP_192912159.1
Coordinates 1816320..1816718 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IGS73_RS08730 Protein ID WP_094078827.1
Coordinates 1816114..1816323 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGS73_RS08710 1812010..1812831 - 822 WP_192912262.1 SDR family oxidoreductase -
IGS73_RS08715 1812980..1814005 - 1026 WP_192912157.1 TerC/Alx family metal homeostasis membrane protein -
IGS73_RS08720 1814147..1815592 - 1446 WP_192912158.1 FAD-dependent oxidoreductase -
IGS73_RS08725 1815764..1816093 + 330 WP_084451932.1 single-stranded DNA-binding protein -
IGS73_RS08730 1816114..1816323 + 210 WP_094078827.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IGS73_RS08735 1816320..1816718 + 399 WP_192912159.1 PIN domain nuclease Toxin
IGS73_RS08740 1817010..1817931 + 922 Protein_1720 dihydrodipicolinate synthase family protein -
IGS73_RS08745 1817928..1818452 + 525 WP_192912160.1 hypothetical protein -
IGS73_RS08750 1818517..1818762 + 246 WP_084451938.1 hypothetical protein -
IGS73_RS08755 1819186..1819785 - 600 WP_192912161.1 hypothetical protein -
IGS73_RS08760 1819986..1820486 + 501 WP_084451939.1 hypothetical protein -
IGS73_RS08765 1820522..1821529 + 1008 WP_084451940.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-38)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14381.34 Da        Isoelectric Point: 6.4784

>T176602 WP_192912159.1 NZ_CP062789:1816320-1816718 [Janibacter indicus]
VTLVDTSVWVEYLRGTDSPSTRYVRERLGSDLFTTEPVLMELLAGARPGASTARLERLLLSQSWARLESSLDHRGAVDVF
HACRSDGHPVRSLNDCLIAAAALRVGLPVAHRDADFERIAAVTGLTVVDLRG

Download         Length: 399 bp

>T176602 NZ_CP082840:c2767563-2766241 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7765.81 Da        Isoelectric Point: 4.1964

>AT176602 WP_094078827.1 NZ_CP062789:1816114-1816323 [Janibacter indicus]
MGRTNIEIDDDLIAEAMRRYGLATKREAVDFALRRLVGPVMTREEMLAMEGSGWDGDLDQVRSDPVEPV

Download         Length: 210 bp

>AT176602 NZ_CP082840:c2767829-2767563 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References