Detailed information of TA system TA176600

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4509090..4510663
• Replicon: chromosome
• Accession: NZ_CP062787
• Organism: Aeromonas caviae strain FDAARGOS_72

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: IL332_RS21050
• Protein ID: WP_042864682.1
• Coordinates: 4509090..4510409 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: IL332_RS21055
• Protein ID: WP_042864681.1
• Coordinates: 4510409..4510663 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IL332_RS21035 (IL332_20820)	4505004..4505768	+	765	WP_010672275.1	ATP-binding cassette domain-containing protein	-
IL332_RS21040 (IL332_20825)	4505799..4506692	+	894	WP_042865412.1	ABC transporter substrate-binding protein	-
IL332_RS21045 (IL332_20830)	4506689..4508671	+	1983	WP_042864683.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
IL332_RS21050 (IL332_20835)	4509090..4510409	-	1320	WP_042864682.1	type II toxin-antitoxin system HipA family toxin	Toxin
IL332_RS21055 (IL332_20840)	4510409..4510663	-	255	WP_042864681.1	helix-turn-helix domain-containing protein	Antitoxin
IL332_RS21060 (IL332_20845)	4511202..4511819	+	618	WP_042865410.1	recombinase family protein	-
IL332_RS21065 (IL332_20850)	4511816..4512139	-	324	WP_015848529.1	hypothetical protein	-
IL332_RS21070 (IL332_20855)	4512718..4514505	+	1788	WP_103255138.1	P-loop NTPase fold protein	-
IL332_RS21075 (IL332_20860)	4514505..4515257	+	753	WP_042864680.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49588.58 Da
• Isoelectric Point: 6.8291

>T176600 WP_042864682.1 NZ_CP062787:c4510409-4509090 [Aeromonas caviae]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYIDGRWYLPLKATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYSIEQIFPRHFFQTAKTVGFERSAMEEILTELANSV
DDVIERVTQQLPADFPDTISSTILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T176600 NZ_CP082840:746800-747285 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9320.64 Da
• Isoelectric Point: 7.9834

>AT176600 WP_042864681.1 NZ_CP062787:c4510663-4510409 [Aeromonas caviae]
MKVTNAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT176600 NZ_CP082840:746510-746803 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA