Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2676588..2677059 Replicon chromosome
Accession NZ_CP062782
Organism Escherichia coli O157:H7 strain Z869

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag ILQ35_RS13635 Protein ID WP_001303511.1
Coordinates 2676588..2676866 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag ILQ35_RS13640 Protein ID WP_001302048.1
Coordinates 2676868..2677059 (-) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ35_RS13600 2671594..2671778 - 185 Protein_2656 DUF3596 domain-containing protein -
ILQ35_RS13605 2671813..2672064 - 252 WP_000005552.1 excisionase family protein -
ILQ35_RS13610 2672137..2674608 - 2472 WP_000048458.1 exonuclease -
ILQ35_RS13615 2674701..2674892 - 192 WP_001090200.1 DUF1482 family protein -
ILQ35_RS13620 2674889..2675077 - 189 WP_000449192.1 cell division inhibition protein DicB -
ILQ35_RS13625 2675646..2675864 - 219 WP_001171930.1 hypothetical protein -
ILQ35_RS13630 2675936..2676235 - 300 WP_001240334.1 hypothetical protein -
ILQ35_RS13635 2676588..2676866 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ35_RS13640 2676868..2677059 - 192 WP_001302048.1 hypothetical protein Antitoxin
ILQ35_RS13645 2677080..2677451 - 372 WP_001169686.1 hypothetical protein -
ILQ35_RS13650 2677549..2677851 + 303 WP_000172738.1 transcriptional regulator -
ILQ35_RS13655 2677848..2678273 + 426 WP_000693943.1 Rha family transcriptional regulator -
ILQ35_RS13660 2678296..2679258 + 963 WP_000095669.1 helix-turn-helix domain-containing protein -
ILQ35_RS13665 2679265..2680005 + 741 WP_000788938.1 ATP-binding protein -
ILQ35_RS13670 2680031..2680800 + 770 Protein_2670 DUF1627 domain-containing protein -
ILQ35_RS13675 2680816..2681211 + 396 WP_001118159.1 DUF977 family protein -
ILQ35_RS13680 2681268..2681852 + 585 WP_000206793.1 DUF551 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2663192..2712590 49398


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T176583 WP_001303511.1 NZ_CP062782:c2676866-2676588 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T176583 NZ_CP082835:c3657013-3656678 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT176583 WP_001302048.1 NZ_CP062782:c2677059-2676868 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT176583 NZ_CP082835:c3657261-3657013 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References