Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4956836..4957431 Replicon chromosome
Accession NZ_CP062780
Organism Escherichia coli O157:H7 strain Z1769

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag ILQ49_RS24680 Protein ID WP_000239579.1
Coordinates 4956836..4957186 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID Q8XCF3
Locus tag ILQ49_RS24685 Protein ID WP_001223210.1
Coordinates 4957180..4957431 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ49_RS24660 4952282..4953304 - 1023 WP_001301928.1 ABC transporter permease -
ILQ49_RS24665 4953318..4954820 - 1503 WP_000205806.1 sugar ABC transporter ATP-binding protein -
ILQ49_RS24670 4954960..4955916 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
ILQ49_RS24675 4956226..4956756 + 531 WP_000055075.1 inorganic diphosphatase -
ILQ49_RS24680 4956836..4957186 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
ILQ49_RS24685 4957180..4957431 - 252 WP_001223210.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
ILQ49_RS24690 4957643..4957984 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
ILQ49_RS24695 4957987..4961766 - 3780 WP_000060930.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T176558 WP_000239579.1 NZ_CP062780:c4957186-4956836 [Escherichia coli O157:H7]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T176558 NZ_CP082833:1879520-1880449 [Citrobacter rodentium NBRC 105723 = DSM 16636]
ATGGATCTGCGTGATATTTATGCCCGACAGGTCAGGCTATTAATGACTGCTCTGCCGCTTGTGGCAAAGGAGTCCTGCTT
CGCGCTGAAAGGCGGCACGGCAATCAATTTGTTTGTACAGGATTTCCCTCGCCTGTCGGTGGATATCGATCTTGCTTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGTTGCCATCCATGACGCCCTGATGCGTATTACTAAATCGCTGAATGGCAGG
CCAGGGATCACGGCGATCCGGCAGGAGAATAAAGCGGATGAAAAGCGCATCATCGTTAACACCGCCGATGCGAAGATAAA
GATTGAGGTTAGTCCGGTCTGGCGTGGACTACTGTTGCCACCAACAGAAATGCCAGTATGTGAACAGGTGGAAATGGAAT
ATGGCTTCACCACCATGAATGTTGTCTCGCTGGCGGATCTTTACGGCGGTAAAATCTGCGCTGCGCTTGACCGCCAGCAT
CCACGCGATCTGTTTGACGTGCTGAATATGCTGGAGAAACCGGGTCTGACACGTGAGATCTTTGACGGTTTTCTTTGTTA
TCTGGTAGGCCATCCCCGCCCCATTGCTGAACTGCTGGCACCAAACTGGGACACGACCCAGATCGCCACGCTGTACGCAC
AGGAATTTTCAGGGATGACACAACAGGAAACTTCGCTGGACTCTCTTTTGTCAGTCACAACCTTGCTACCGCAGGCGCTG
AAATCGCACCTTACGGGCAAAGATCGCCAGTTCCTGCTCACCTATAAGCAAAATACTCCTGACTGGTCGCTGTATCGCTA
TCCTGAAATTCAACACCTACCGGCTATTCGCTGGAAGTTGCGTAACCTGGAGGTGCTGAATGATAAGAATCCGGCCAAGT
ATGCAGCGGCAGTGAGTAAGCTGGAGGGGGTTCTGAAGCAGTATTTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9299.64 Da        Isoelectric Point: 4.4201

>AT176558 WP_001223210.1 NZ_CP062780:c4957431-4957180 [Escherichia coli O157:H7]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT176558 NZ_CP082833:1878751-1879533 [Citrobacter rodentium NBRC 105723 = DSM 16636]
TTGGCAAACTATCTAAACTGGCTGATGCAGAACACCCTCCCCGGTCAGGTTTTGCTCCAGTCATGGCTCACCCGCAATGG
CATAGATCGTAAGCTCTCTTACCTCTATGTGCAGAATGACTGGCTCAGGCGGATCGCGCACGGCGTATATTGTCGGACGG
GCCGTGAGCCGAACTGGGTGGACGCAGTTTACTGTCTGCAAACGCAGTGGGGGAAAAAAGTTCGCGTGGCGGGGCTGACC
AGCCTTGCGCTACAGGGCCACGCTCACTATACCGAACCGGGTAGACAACAAATCTGGCTTGCACTACCGGCTTACGTCAA
ACTGCCGGGATGGTTCACCGCCTTTGAGCAATCCGCGACGTTTGTCACGCTGTATACCTCTGGTCTCACCGTCGATACAA
CACTATTCGCAACAAAACTAAATATCGGCGACCGGCAGTTAATGGGCAGTGTCCCGGAACTGGCCGCATATGAGATAGCC
TGCGGCGTTCCTTCGTTGATCTCCTTCGAACATGCCGACGCTCTGTTTCAGGGGATGAATCTTCTCAGCCCGCGTAAATT
ACAGACACTGCTCTGCGCCAGTCATTCGGTTAAAACCAACCGGGTGATGCTTTACCTTGCCCGACGCAATGAGCATCCTT
ACTTTCAGTATCTCGATCAAAGCGGTATAGAAACAGGCACGGGAAAACGGCAAATTGTTCCCGGCGGCTGGCTGGAACCG
GATTATCAAATCACCGTTCCCCGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure

References