Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3579623..3580101 Replicon chromosome
Accession NZ_CP062780
Organism Escherichia coli O157:H7 strain Z1769

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ49_RS18410 Protein ID WP_001303876.1
Coordinates 3579814..3580101 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ49_RS18405 Protein ID WP_000536233.1
Coordinates 3579623..3579814 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ49_RS18370 3575027..3575797 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ49_RS18375 3575819..3576565 - 747 WP_000788751.1 ATP-binding protein -
ILQ49_RS18380 3576572..3577663 - 1092 WP_001205823.1 hypothetical protein -
ILQ49_RS18385 3577742..3578197 + 456 WP_000273724.1 hypothetical protein -
ILQ49_RS18390 3578404..3578829 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ49_RS18395 3578813..3579085 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ49_RS18400 3579194..3579595 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ49_RS18405 3579623..3579814 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ49_RS18410 3579814..3580101 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ49_RS18415 3580379..3580534 + 156 WP_000379575.1 DUF1391 family protein -
ILQ49_RS18420 3580676..3581065 + 390 WP_000394511.1 hypothetical protein -
ILQ49_RS18425 3581252..3581437 - 186 WP_001133046.1 hypothetical protein -
ILQ49_RS18430 3582011..3582199 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ49_RS18435 3582196..3582387 + 192 WP_001098307.1 DUF1482 family protein -
ILQ49_RS18440 3582481..3584952 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T176550 WP_001303876.1 NZ_CP062780:3579814-3580101 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T176550 NZ_CP082832:850-1155 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT176550 WP_000536233.1 NZ_CP062780:3579623-3579814 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT176550 NZ_CP082832:630-848 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References