Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3578608..3579086 Replicon chromosome
Accession NZ_CP062774
Organism Escherichia coli O157:H7 strain Z563

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ31_RS18415 Protein ID WP_001303876.1
Coordinates 3578799..3579086 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ31_RS18410 Protein ID WP_000536233.1
Coordinates 3578608..3578799 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ31_RS18375 3574012..3574782 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ31_RS18380 3574804..3575550 - 747 WP_000788751.1 ATP-binding protein -
ILQ31_RS18385 3575557..3576648 - 1092 WP_001205823.1 hypothetical protein -
ILQ31_RS18390 3576727..3577182 + 456 WP_000273724.1 hypothetical protein -
ILQ31_RS18395 3577389..3577814 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ31_RS18400 3577798..3578070 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ31_RS18405 3578179..3578580 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ31_RS18410 3578608..3578799 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ31_RS18415 3578799..3579086 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ31_RS18420 3579364..3579519 + 156 WP_000379575.1 DUF1391 family protein -
ILQ31_RS18425 3579661..3580050 + 390 WP_000394511.1 hypothetical protein -
ILQ31_RS18430 3580237..3580422 - 186 WP_001133046.1 hypothetical protein -
ILQ31_RS18435 3580996..3581184 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ31_RS18440 3581181..3581372 + 192 WP_001098307.1 DUF1482 family protein -
ILQ31_RS18445 3581466..3583937 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T176475 WP_001303876.1 NZ_CP062774:3578799-3579086 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T176475 NZ_CP082823:c5006910-5006611 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT176475 WP_000536233.1 NZ_CP062774:3578608-3578799 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT176475 NZ_CP082823:c5006614-5006324 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References