Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3794405..3795110 Replicon chromosome
Accession NZ_CP062771
Organism Escherichia coli O157:H7 strain Z570

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag ILQ32_RS19495 Protein ID WP_000539519.1
Coordinates 3794405..3794791 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ILQ32_RS19500 Protein ID WP_001280945.1
Coordinates 3794781..3795110 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ32_RS19475 3790409..3791035 + 627 WP_001295292.1 glutathione S-transferase GstB -
ILQ32_RS19480 3791032..3792147 - 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
ILQ32_RS19485 3792258..3792641 - 384 WP_000497137.1 biofilm formation regulator BssR -
ILQ32_RS19490 3792854..3794179 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
ILQ32_RS19495 3794405..3794791 + 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ32_RS19500 3794781..3795110 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
ILQ32_RS19505 3795180..3796508 - 1329 WP_000086905.1 GGDEF domain-containing protein -
ILQ32_RS19510 3796516..3798864 - 2349 WP_000950320.1 EAL domain-containing protein -
ILQ32_RS19515 3799042..3799953 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T176438 WP_000539519.1 NZ_CP062771:3794405-3794791 [Escherichia coli O157:H7]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T176438 NZ_CP082815:c2122667-2122416 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT176438 WP_001280945.1 NZ_CP062771:3794781-3795110 [Escherichia coli O157:H7]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT176438 NZ_CP082815:c2122426-2122244 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References