Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3628251..3628729 Replicon chromosome
Accession NZ_CP062771
Organism Escherichia coli O157:H7 strain Z570

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ32_RS18755 Protein ID WP_001303876.1
Coordinates 3628442..3628729 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ32_RS18750 Protein ID WP_000536233.1
Coordinates 3628251..3628442 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ32_RS18715 3623655..3624425 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ32_RS18720 3624447..3625193 - 747 WP_000788751.1 ATP-binding protein -
ILQ32_RS18725 3625200..3626291 - 1092 WP_001205823.1 hypothetical protein -
ILQ32_RS18730 3626370..3626825 + 456 WP_000273724.1 hypothetical protein -
ILQ32_RS18735 3627032..3627457 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ32_RS18740 3627441..3627713 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ32_RS18745 3627822..3628223 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ32_RS18750 3628251..3628442 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ32_RS18755 3628442..3628729 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ32_RS18760 3629007..3629162 + 156 WP_000379575.1 DUF1391 family protein -
ILQ32_RS18765 3629304..3629693 + 390 WP_000394511.1 hypothetical protein -
ILQ32_RS18770 3629880..3630065 - 186 WP_001133046.1 hypothetical protein -
ILQ32_RS18775 3630639..3630827 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ32_RS18780 3630824..3631015 + 192 WP_001098307.1 DUF1482 family protein -
ILQ32_RS18785 3631109..3633580 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T176437 WP_001303876.1 NZ_CP062771:3628442-3628729 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T176437 NZ_CP082815:c2099232-2099056 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT176437 WP_000536233.1 NZ_CP062771:3628251-3628442 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT176437 NZ_CP082815:2098933-2098988 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References