Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3534139..3534617 Replicon chromosome
Accession NZ_CP062769
Organism Escherichia coli O157:H7 strain Z852

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ33_RS18105 Protein ID WP_001303876.1
Coordinates 3534330..3534617 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ33_RS18100 Protein ID WP_000536233.1
Coordinates 3534139..3534330 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ33_RS18065 3529543..3530313 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ33_RS18070 3530335..3531081 - 747 WP_000788751.1 ATP-binding protein -
ILQ33_RS18075 3531088..3532179 - 1092 WP_001205823.1 hypothetical protein -
ILQ33_RS18080 3532258..3532713 + 456 WP_000273724.1 hypothetical protein -
ILQ33_RS18085 3532920..3533345 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ33_RS18090 3533329..3533601 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ33_RS18095 3533710..3534111 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ33_RS18100 3534139..3534330 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ33_RS18105 3534330..3534617 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ33_RS18110 3534895..3535050 + 156 WP_000379575.1 DUF1391 family protein -
ILQ33_RS18115 3535192..3535581 + 390 WP_000394511.1 hypothetical protein -
ILQ33_RS18120 3535768..3535953 - 186 WP_001133046.1 hypothetical protein -
ILQ33_RS18125 3536527..3536715 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ33_RS18130 3536712..3536903 + 192 WP_001098307.1 DUF1482 family protein -
ILQ33_RS18135 3536997..3539468 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T176401 WP_001303876.1 NZ_CP062769:3534330-3534617 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T176401 NZ_CP082799:c5075902-5075519 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT176401 WP_000536233.1 NZ_CP062769:3534139-3534330 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT176401 NZ_CP082799:c5076144-5075902 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References